2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipoxygenase

Lipoxygenase

LOX

Lipoxygenase

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Lipoxygenases (LOXs) are a family of enzymes that are responsible for the metabolism of arachidonic and docosahexaenoic acid and for the formation of several eicosanoids and docosanoids, including leukotrienes, lipoxins and neuroprotectins. Depending on cells' redox state and other milieu conditions, these enzymes are engaged in oxidative stress and cell death mechanisms or in cell protection. Lipoxygenases are lipid peroxidizing enzymes, implicated in the pathogenesis of inflammatory and hyperproliferative diseases, which represent potential targets for pharmacological intervention.

Lipoxygenases are classified on the basis of site of arachidonate oxygenation into 5-, 8-, 9-, 11-, 12- and 15-LOX. The prominent animal LOXs are 5-LOX, 8-LOX, 12-LOX and 15-LOX, while the plant LOXs are mostly 5-LOX and 15-LOX. Among these, 5-LOX is the most predominant isoform associated with the formation of 5-hydroperoxyeicosatetraenoic acid (5-HpETE) and other bioactive lipid mediators.

Lipoxygenase Isoform Specific Products:

Lipoxygenase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N7156
    2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone
    		Inhibitor
    2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone, isolated from Parinari hypochrysea (Chrysobalanaceae), exhibits antioxidant and lipoxygenase inhibition.
    2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone
  • HY-138979
    Lipoxygenin
    		Inhibitor
    Lipoxygenin is a non-redox 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. Lipoxygenin modulates the β-catenin-5-LO complex, inducing a decrease in β-catenin and 5-LO levels in the nucleus.
    Lipoxygenin
  • HY-116866
    Sclerotiorin
    		Inhibitor
    Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC50: 4.2 μM). Sclerotiorin also shows antioxidant activity by scavenging free radical (ED50: 0.12 μM), and nonenzymatic lipid peroxidation inhibition activity. Sclerotiorin has antifungal activity, and also inhibits platelet aggregation. Sclerotiorin can be purified from the fermented broth of Penicillium frequentans.
    Sclerotiorin
  • HY-163188
    COX-2/LOX-IN-2
    		Inhibitor
    COX-2/LOX-IN-2 (compound 6) is a dual inhibitor of COX-2/LOX with IC50s of 7.0 μM and 27.5 μM, respectively. COX-2/LOX-IN-2 has antioxidant activity and has the potential to be used in the development of nonsteroidal anti-inflammatory drugs (tNSAIDs).
    COX-2/LOX-IN-2
  • HY-116124
    17(S)-HpDHA
    17(S)-HpDHA is the main 15-Lipoxygenase (LOX) isoenzyme: h15-LOX-1 and h15-LOX-2 and docosahexaenoic acid (DHA). product. 17(S)-HpDHA negatively regulates epoxide synthesis via allosteric regulation. 17(S)-HpDHA also inhibits platelet aggregation with an EC50 of approximately 1 μM.
    17(S)-HpDHA
  • HY-N0493R
    Pectolinarigenin (Standard)
    		Inhibitor
    Pectolinarigenin (Standard) is the analytical standard of Pectolinarigenin. This product is intended for research and analytical applications. Pectolinarigenin is a dual inhibitor of COX-2/5-LOX. Anti-inflammatory activity. Pectolinarigenin has potent inhibitory activities on melanogenesis.
    Pectolinarigenin (Standard)
  • HY-120495
    EP6
    		Inhibitor
    EP6 is a potent 5-Lipoxygenase (5-LO) inhibitor. EP6 inhibits the cell viability of tumor cells without mutagenic activity. EP6 can be used in research of cancer.
    EP6
  • HY-126898
    5-LO/mPGES1-IN-1
    		Inhibitor
    5-LO/mPGES1-IN-1 (Compound 16) is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO). IC50 values are 0.3 and 0.4 μM, respectively. 5-LO/mPGES1-IN-1 has anti-inflammatory activity.
    5-LO/mPGES1-IN-1
  • HY-114796
    tHGA
    		Inhibitor
    tHGA is a compound with anti-inflammatory activity and has the activity to inhibit soybean 15-LOX. tHGA showed significant inhibitory effects in experiments on human leukocytes, with an IC50 value of 0.42 μM, which is close to the effect of commonly used standard NDGA. tHGA concentration-dependently inhibits the synthesis of 5-LOX products, especially the cysteine leukotriene LTC(4), with an IC50 value of 1.80 μM. and showed no cytotoxicity. The anti-inflammatory effects of tHGA do not appear to be through redox or metal chelation mechanisms, as the compound was negative in these bioactivity tests. tHGA works through a dual LOX/COX inhibition mechanism and has higher selectivity for 5-LOX and COX-2, with an IC50 value of 0.40 μM.
    tHGA
  • HY-155409
    ALR-38
    		Antagonist
    ALR-38 is a 5-lipoxygenase (5-LOX) inhibitor (IC50: 1.1 μM) with anti-inflammatory activity. ALR-38 effectively reduces ROS levels in neutrophils.
    ALR-38
  • HY-114372
    Lycopodine
    		Inhibitor
    Lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatumspores, triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in refractory prostate cancer cells without modulating p53 activity. Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation.
    Lycopodine
  • HY-162166
    COX-2/15-LOX/mPGES1-IN-1
    		Inhibitor
    COX-2/15-LOX/mPGES1-IN-1 (Compound 2c) is an inhibitor of COX-2, 15-LOX, and mPGES-1 enzymes with IC50 values of 0.057, 2.39, and 2.8 μM, respectively. COX-2/15-LOX/mPGES1-IN-1 possesses anti-inflammatory activity and can inhibit rat paw edema in vivo experiments.
    COX-2/15-LOX/mPGES1-IN-1
  • HY-100148
    ICI 211965
    		Inhibitor
    ICI 211965 (ZM-211965) is a selective and orally potent 5-Lipoxygenase (5-LPO) inhibitor.
    ICI 211965
  • HY-159169
    5-LOX/sEH-IN-1
    		Inhibitor
    5-LOX/sEH-IN-1 (Compound 8o) is a dual 5-LOX/sEH-IN-1 inhibitor with cardioprotective effects, exhibiting IC50 values of 3.05 μM and 2.20 nM respectively, and 5-LOX/sEH-IN-1 can also inhibit the activity of COX-2 (IC50=10.50 μM). 5-LOX/sEH-IN-1 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects.
    5-LOX/sEH-IN-1
  • HY-B1452S1
    Licofelone-d6
    Licofelone-d6 is the deuterium labeled Licofelone[1]. Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[2][3][4].
    Licofelone-d<sub>6</sub>
  • HY-124674
    CCT365623
    CCT365623 is a potent and orally active LOX inhibitor with an IC50 of 0.9 μM. CCT365623 has potent anti-metastatic efficacy in vivo.
    CCT365623
  • HY-N8480
    Atractylochromene
    		Inhibitor
    Atractylochromene is a potent dual inhibitor of 5-LOX/COX-1 with IC50s of 0.6 and 3.3 μM, respectively.
    Atractylochromene
  • HY-121099
    Cgp 8065
    		Inhibitor
    L-689065 is a 5-lipoxygenase inhibitor.
    Cgp 8065
  • HY-151173
    XO/COX/LOX-IN-1
    		Inhibitor
    XO/COX/LOX-IN-1 (compound 7i) is a potent xanthine oxidase/cyclooxygenases/lipoxygenases (XO/COX/LOX) inhibitor. XO/COX/LOX-IN-1 can be used in studies of inflammation, cancer and metabolic diseases.
    XO/COX/LOX-IN-1
  • HY-N9115
    Plathymenin
    		Inhibitor
    Plathymenin is a flavonoid that can be isolated from Nepalese propolis. Plathymenin is a potent inhibitor of 5-LOX.
    Plathymenin
Cat. No. Product Name / Synonyms Application Reactivity
Lipoxygenase Isoform Comparison

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