2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipoxygenase
  5. 15-LOX Isoform
  6. 15-LOX Inhibitor

15-LOX Inhibitor

15-LOX Inhibitors (5):

Cat. No. Product Name Effect Purity
  • HY-138989
    15-LOX-1 inhibitor 1
    		Inhibitor 98.60%
    15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation.
  • HY-N11058
    Damnacanthol
    		Inhibitor 99.76%
    Damnacanthol is a natural product that can be isolated from Damnacanthus major. Damnacanthol has anti-15-lipoxygenase activity and can inhibit nitric oxide production in LPS-activated macrophages RAW 264.7 cells.
  • HY-161315
    15-LOX-IN-1
    		Inhibitor
    15-LOX-IN-1 (Compound 7c) is a 15-LOX inhibitor with a IC50 value of 1.92 μM. 15-LOX-IN-1 has anti-inflammatory activity.
  • HY-N12987
    Caffeoylcalleryanin
    		Inhibitor
    Caffeoylcalleryanin is a potent 15-lipoxygenase inhibitor with an IC50 value of 1.59 µM. Caffeoylcalleryanin shows no cytotoxic.
  • HY-150548
    COX-2/15-LOX-IN-1
    		Inhibitor
    COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and 15-lipoxygenase enzyme (15-LOX) inhibitor with IC50 values of 10.65, 0.075 and 2.98 μM against COX-1, COX-2 and 15-LOX, respectively. COX-2/15-LOX-IN-1 shows anti-inflammatory activity.