2. Signaling Pathways
  3. Antibody-drug Conjugate/ADC Related
  4. ADC Cytotoxin
  5. Camptothecins Isoform

Camptothecins

The anti-tumor activity of Camptothecin (CPT) and its derivatives is mainly due to its interaction with Topoisomerase 1 (TOP1), a ubiquitous enzyme involved in the regulation of DNA topology during replication, recombination and transcription. TOP1 forms a phosphotyrosine bond with DNA, catalyzing a forward reaction in which DNA is cleaved to allow unwinding, and a reverse reaction in which DNA is religated. CPT interferes with the religation step of this process by reversibly binding to and stabilizing the enzyme/DNA complex. Once the CPT molecule has intercalated into the TOP1-DNA complex (cleavable complex), the collision between the complex and the replication fork during S-phase is thought to result in DNA double strand breaks (DSBs) that eventually lead to cell death.

Camptothecins Related Products (43):

Cat. No. Product Name Effect Purity
  • HY-400316
    Exatecan intermediate 8
    Exatecan intermediate 8 is an intermediate for the synthesis of Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM).
  • HY-46081
    Exatecan Intermediate 3
    Exatecan Intermediate 3 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 3 can be used to synthesize Antibody-Drug Conjugates (ADCs).
  • HY-160543
    Exatecan-amide-CH2-O-CH2-CH2-OH
    Exatecan-amide-CH2-O-CH2-CH2-OH (Compound 4) is a derivative of Exatecan (HY-13631). Exatecan-amide-CH2-O-CH2-CH2-OH can be used for the research of cell proliferative diseases such as cancer.