2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. Ack1
  5. Ack1 Inhibitor

Ack1 Inhibitor

Ack1 Inhibitors (7):

Cat. No. Product Name Effect Purity
  • HY-15290
    AIM-100
    		Inhibitor 99.95%
    AIM-100 is a potent and selective Ack1 inhibitor with an IC50 of 21.58 nM. AIM-100 also inhibits Tyr267 phosphorylation. AIM-100 does not inhibits other kinases including PI3-kinase and AKT subfamily members. AIM-100 has an anticancer effect.
  • HY-10943
    GNF-7
    		Inhibitor 99.70%
    GNF-7 is a multikinase inhibitor. GNF-7 is a Bcr-Abl inhibitor, with IC50s of 133 nM and 61 nM for Bcr-AblWT and Bcr-AblT315I, respectively. GNF-7 also possesses inhibitory activity against both ACK1 (activated CDC42 kinase 1) and GCK (germinal center kinase) with IC50s of 25 nM and 8 nM, respectively. GNF-7 can be used for the research of hematologic malignancies.
  • HY-12331
    KRCA-0008
    		Inhibitor
    KRCA-0008 is a selective ALK/Ack1 inhibitor with IC50s of 12 and 4 nM for ALK and Ack1, respectively. KRCA-0008 can be used for the research of cancer.
  • HY-162254
    EGFR/ACK1-IN-1
    		Inhibitor
    EGFR T790M/L858R/ACK1-IN-1 is a dual inhibitor of EGFR T790M/L858R and ACK1. IC50 values are 23 and 263 nM, respectively. EGFR T790M/L858R/ACK1-IN-1 can inhibit cell proliferation and has antitumor activity.
  • HY-113787
    (R)-9b
    		Inhibitor
    (R)-9b is a potent inhibitor of ACK1 tyrosine kinase (IC50=56 nM) with anticancer activity. (R)-9b exhibits selectivity for ACK1 but has inhibitory effects on JAK family kinases JAK2 and Tyk2. (R)-9b can be used in the study of hormone-regulated cancers such as prostate and breast cancer.
  • HY-149989
    Ack1 inhibitor 1
    		Inhibitor
    Ack1 inhibitor 1 is a potent, selective, and orally active inhibitor of ACK1 kinase with an IC50 value of 2.1 nM. Ack1 inhibitor 1 inhibits the phosphorylation of ACK1 and activation of downstream AKT. Ack1 inhibitor 1 has anti-tumor activity.
  • HY-160635
    Ack1 inhibitor 2
    		Inhibitor
    Ack1 inhibitor 2 (Example 259) is an Ack1 inhibitor (IC50: 0.46 μM).