2. Protein Tyrosine Kinase/RTK Stem Cell/Wnt JAK/STAT Signaling Epigenetics
  3. Ack1 JAK
  4. (R)-9b

(R)-9b is a potent inhibitor of ACK1 tyrosine kinase (IC50=56 nM) with anticancer activity. (R)-9b exhibits selectivity for ACK1 but has inhibitory effects on JAK family kinases JAK2 and Tyk2. (R)-9b can be used in the study of hormone-regulated cancers such as prostate and breast cancer.

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(R)-9b Chemical Structure

(R)-9b Chemical Structure

CAS No. : 1655527-68-6

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5 mg USD 112 In-stock
10 mg USD 180 In-stock
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Based on 1 publication(s) in Google Scholar

(R)-9b Related Antibodies

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JAK1 JAK2 JAK3 Tyk2 JAK

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Description

(R)-9b is a potent inhibitor of ACK1 tyrosine kinase (IC50=56 nM) with anticancer activity. (R)-9b exhibits selectivity for ACK1 but has inhibitory effects on JAK family kinases JAK2 and Tyk2. (R)-9b can be used in the study of hormone-regulated cancers such as prostate and breast cancer[1].

IC50 & Target[1]

JAK2

 

Tyk2

 

Molecular Weight

402.92

Formula

C20H27ClN6O
CAS No.
Appearance

Solid

SMILES

CN1CCN(C2=CC=C(NC3=NC=C(Cl)C(NC[C@@H]4OCCC4)=N3)C=C2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (62.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4819 mL 12.4094 mL 24.8188 mL
5 mM 0.4964 mL 2.4819 mL 4.9638 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4819 mL 12.4094 mL 24.8188 mL 62.0471 mL
5 mM 0.4964 mL 2.4819 mL 4.9638 mL 12.4094 mL
10 mM 0.2482 mL 1.2409 mL 2.4819 mL 6.2047 mL
15 mM 0.1655 mL 0.8273 mL 1.6546 mL 4.1365 mL
20 mM 0.1241 mL 0.6205 mL 1.2409 mL 3.1024 mL
25 mM 0.0993 mL 0.4964 mL 0.9928 mL 2.4819 mL
30 mM 0.0827 mL 0.4136 mL 0.8273 mL 2.0682 mL
40 mM 0.0620 mL 0.3102 mL 0.6205 mL 1.5512 mL
50 mM 0.0496 mL 0.2482 mL 0.4964 mL 1.2409 mL
60 mM 0.0414 mL 0.2068 mL 0.4136 mL 1.0341 mL
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(R)-9b Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-9b1655527-68-6Ack1JAKActivated Cdc42 kinase 1TNK2Janus kinaseTyrosine kinasesinhibitorsprostate cancerbreast cancerInhibitorinhibitorinhibit

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