2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Aldose Reductase

Aldose Reductase

Aldose Reductase

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Aldose reductase is a small, cytosolic, monomeric enzyme which belongs to the aldo-keto reductase superfamily. Aldose reductase catalyzes the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of a wide variety of aromatic and aliphatic carbonyl compounds. It is implicated in the development of diabetic and galactosemic complications involving the lens, retina, nerves, and kidney.

Aldose reductase is both the key enzyme of the polyol pathway, whose activation under hyperglycemic conditions leads to the development of chronic diabetic complications, and the crucial promoter of inflammatory and cytotoxic conditions, even under a normoglycemic status. Aldose reductase represents an excellent drug target and a huge effort is being done to disclose novel compounds able to inhibit it.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-163609
    PROTAC AKR1C3 degrader-1
    		Degrader
    PROTAC AKR1C3 degrader-1 (compound 5) is a potent AKR1C3 PROTAC degrader. PROTAC AKR1C3 degrader-1 decreases the protein expression of AKR1C3, AKR1C1/2, and ARv7. PROTAC AKR1C3 degrader-1 has the potential for the research of prostate cancer. (Blue:ubiquitin E3 ligase cereblon ligand (HY-A0003), Black: linker (HY-163647); Pink: AKR1C3 inhibitor (HY-163610)).
    PROTAC AKR1C3 degrader-1
  • HY-D0064
    6,7-Dihydroxy-4-coumarinylacetic acid
    		Inhibitor
    6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC50s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation.
    6,7-Dihydroxy-4-coumarinylacetic acid
  • HY-105485
    FR-62765
    		Inhibitor
    FR-62765 is a derivative of WF-3681. FR-62765 can significantly inhibit the accumulation of sorbitol in the sciatic nerve and the decrease of motor nerve conduction velocity in the tail of diabetic neuropathy rats, which can be used in the research of diabetic neuropathy.
    FR-62765
  • HY-144749
    AKR1C3-IN-5
    		Inhibitor
    AKR1C3-IN-5 (Compound 6e) is a potent inhibitor of AKR1C3. AKR1C3 enzyme is overexpressed in hormone-dependent prostate and breast tumors. AKR1C3-IN-5 derived from drupanin, which exhibits half-maximal inhibitory concentration (IC50) of 9.6 ± 3 μM and selectivity index (SI) of 5.5 against MCF-7 cells.
    AKR1C3-IN-5
  • HY-150648
    S07-2008
    		Inhibitor
    S07-2008 is a selective aldo-keto reductase family 1 member C3 (AKR1C3) inhibitor with an IC50 of 0.16 μM. S07-2008 shows anticancer activities.
    S07-2008
  • HY-147875
    Aldose reductase-IN-6
    		Inhibitor
    Aldose reductase-IN-6 (Compound 3) is a competitive aldose reductase (AR) inhibitor with an IC50 of 3.164 μM and a Ki of 0.018 μM. Aldose reductase-IN-6 exhibits no cytotoxicity against healthy cells.
    Aldose reductase-IN-6
  • HY-173132
    AKR1Cs-IN-1
    		Inhibitor
    AKR1Cs-IN-1 (Compound 29) is a potent and broad-spectrum inhibitor targeting members of the Aldo-Keto Reductase 1C family (AKR1C1-1C4). By simultaneously occupying the SP2 and SP3 pockets, it effectively inhibits multiple isoforms and disrupts metabolic pathways associated with drug resistance. In enzymatic activity assays, AKR1Cs-IN-1 exhibited significant inhibitory potency, with IC50 values of 0.09, 0.28, 0.05, and 0.51 µM against AKR1C1, AKR1C2, AKR1C3, and AKR1C4, respectively. In the doxorubicin (DOX)-resistant breast cancer cell line MCF-7/ADR, AKR1Cs-IN-1 showed remarkable resensitization effects and significantly enhanced the cytotoxicity of DOX. AKR1Cs-IN-1 holds promise for research on overcoming drug resistance in breast cancer.
    AKR1Cs-IN-1
  • HY-157810
    AKR1C3-IN-11
    		Inhibitor
    AKR1C3-IN-11 (Compound 6e) is a Aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 of 2.0 μM. AKR1C3-IN-11 inhibit cell proliferation in combination with abiraterone (HY-70013). AKR1C3-IN-11 can be used for the research of prostate cancer.
    AKR1C3-IN-11
  • HY-N14447
    Salfredin A3
    		Inhibitor
    Salfredin A3 is an aldose reductase inhibitor.
    Salfredin A3
  • HY-N14186
    Asperaldin
    		Inhibitor
    Asperaldin is a potent aldose reductase (RLAR) inhibitor found in Aspergillus niger CFR-1046.
    Asperaldin
  • HY-N14431
    Salfredin C2
    		Inhibitor
    Salfredin C2 is an aldose reductase inhibitor.
    Salfredin C2
  • HY-16500R
    Tolrestat (Standard)
    		Inhibitor
    Tolrestat (Standard) is the analytical standard of Tolrestat. This product is intended for research and analytical applications. Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM.
    Tolrestat (Standard)
  • HY-N14419
    Salfredin C3
    		Inhibitor
    Salfredin C3 is an aldose reductase inhibitor.
    Salfredin C3
  • HY-N14449
    Salfredin A4
    		Inhibitor
    Salfredin A4 is an aldose reductase inhibitor.
    Salfredin A4
  • HY-N12472
    Floramanoside C
    		Inhibitor
    Floramanoside C shows 2,2-diphenyl-1-picrylhydrazyl scavenging and aldose reductase inhibitory activities.
    Floramanoside C
  • HY-W319094
    4′-Hydroxyflavone
    		Inhibitor
    4′-Hydroxyflavone (compound 50) can inhibit aldose reductase, with a log1/IC50 of 4.92.
    4′-Hydroxyflavone
  • HY-155164
    WF-3681
    		Inhibitor
    WF-3681 (compound 1) is an aldose reductase inhibitor and a fungal metabolite.
    WF-3681
  • HY-N14401
    Salfredin B11
    		Inhibitor
    Salfredin B11 is an aldose reductase inhibitor.
    Salfredin B11
  • HY-W011786
    2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole
    		Inhibitor
    2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole is an inhibitor of larval settlement in marine organisms, demonstrating low toxicity while effectively inhibiting the metamorphosis of species such as barnacles, bryozoans, and polychaetes. 2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole also exhibits activity as an aldose reductase (ALR2) inhibitor, indicating potential therapeutic applications in diabetes-related complications.
    2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole
  • HY-B1202A
    Alrestatin sodium
    		Inhibitor
    Alrestatin sodium is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.
    Alrestatin sodium
Cat. No. Product Name / Synonyms Application Reactivity