BMI1

Bmi-1; B cell-specific Moloney murine leukemia virus integration site 1

B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), a component of the polycomb repressive complex 1 (PRC1), is recognized as a polycomb protein that prevents premature senescence and maintains the self-renewal capacity of stem cells.

BMI1 Inhibitors (7)

BMI1 Related Products (7):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-15888

PTC-209	Inhibitor	99.85%
PTC-209 is a specific BMI-1 inhibitor with an IC₅₀ of 0.5 μM in HEK293T cell line. PTC-209 irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 shows potent anti-myeloma activity and impairs the tumor microenvironment.

HY-112041

Unesbulin	Inhibitor	99.45%
Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity.

HY-103696

PTC-028	Inhibitor	≥98.0%
PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. PTC-028 downregulates BMI-1, inducing caspase-mediated apoptosis.

HY-15888A

PTC-209 hydrobromide	Inhibitor	99.44%
PTC-209 hydrobromide is a specific BMI-1 inhibitor with an IC₅₀ of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment.

HY-143658

SH498	Inhibitor
SH498, a novel Bmi-1-mediated antitumor agent, shows potent antiproliferative activity.

HY-143655

QW24	Inhibitor
QW24 exerts potent anti-tumor activity by down-regulating BMI-1 and is used as an effective therapeutic agent for clinical colorectal cancer research.

HY-N0992

1,6,7-Trihydroxyxanthone	Inhibitor
1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16.

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