2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. BRK

BRK

Breast tumor kinase; Protein tyrosine kinase 6 (PTK6)

 
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-110244
    Tilfrinib
    		Inhibitor 99.69%
    Tilfrinib (compound 4f) is a potent and selective Brk/PTK6 inhibitor with an IC50 value of 3.15 nM for Brk. Tilfrinib shows good anti-proliferative activity and has potential of anti-tumour.
    Tilfrinib
  • HY-108333
    SB-633825
    		Inhibitor 98.52%
    SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis.
    SB-633825
  • HY-115514A
    BRK inhibitor P21d hydrochloride
    		Inhibitor ≥98.0%
    BRK inhibitor P21d hydrochloride is a potent breast tumor kinase (BRK/PTK6) inhibitor with an IC50 of 30 nM. BRK inhibitor P21d hydrochloride inhibits p-SAM68 with an IC50 of 52 nM. BRK inhibitor P21d hydrochloride can be used to evaluate the in vivo activity of BRK inhibitors in xenograft breast tumor models.
    BRK inhibitor P21d hydrochloride
  • HY-122664
    XMU-MP-2
    		Inhibitor 99.29%
    XMU-MP-2 is a BRK inhibitor with significant inhibitory activity on BRK-positive cells. XMU-MP-2 inhibits oncogenic BRK-driven tumor growth in a mouse xenograft model. XMU-MP-2 also synergizes with HER2 inhibitors or endoplasmic reticulum (ER) blockade to exert antiproliferative activity.
    XMU-MP-2
  • HY-155227S
    ALK/EGFR-IN-1-d5
    		Inhibitor
    ALK/EGFR-IN-1-d5 (Compound (-)-9a) is a deuterated dual-target inhibitor of EGFR and ALK, with an IC50 of 1.08 nM for EGFR and an IC50 of 2.395 nM for ALK. ALK/EGFR-IN-1-d5 inhibits the phosphorylated proteins in the EGFR, ALK, and BRK signaling pathways, blocking the cell cycle, leading to a reduction in mitochondrial membrane potential and cell apoptosis (Apoptosis). ALK/EGFR-IN-1-d5 also significantly inhibits tumor growth in animal models and demonstrates good safety. ALK/EGFR-IN-1-d5 holds promise for research in the field of cancer treatment
    ALK/EGFR-IN-1-d5
Cat. No. Product Name / Synonyms Application Reactivity