2. Protein Tyrosine Kinase/RTK
  3. BRK
  4. XMU-MP-2

XMU-MP-2 is a BRK inhibitor with significant inhibitory activity on BRK-positive cells. XMU-MP-2 inhibits oncogenic BRK-driven tumor growth in a mouse xenograft model. XMU-MP-2 also synergizes with HER2 inhibitors or endoplasmic reticulum (ER) blockade to exert antiproliferative activity.

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XMU-MP-2 Chemical Structure

XMU-MP-2 Chemical Structure

CAS No. : 2031152-10-8

Size Price Stock Quantity
1 mg USD 345 In-stock
5 mg USD 865 In-stock
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Based on 1 publication(s) in Google Scholar

XMU-MP-2 Related Antibodies

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Description

XMU-MP-2 is a BRK inhibitor with significant inhibitory activity on BRK-positive cells. XMU-MP-2 inhibits oncogenic BRK-driven tumor growth in a mouse xenograft model. XMU-MP-2 also synergizes with HER2 inhibitors or endoplasmic reticulum (ER) blockade to exert antiproliferative activity[1].

Molecular Weight

618.65

Formula

C32H33F3N8O2
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC=C(N5CCC(O)CC5)N=C4)N=C3N(C)C2)=C1)C6=CC=CC(C(F)(F)F)=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (80.82 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6164 mL 8.0821 mL 16.1642 mL
5 mM 0.3233 mL 1.6164 mL 3.2328 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6164 mL 8.0821 mL 16.1642 mL 40.4106 mL
5 mM 0.3233 mL 1.6164 mL 3.2328 mL 8.0821 mL
10 mM 0.1616 mL 0.8082 mL 1.6164 mL 4.0411 mL
15 mM 0.1078 mL 0.5388 mL 1.0776 mL 2.6940 mL
20 mM 0.0808 mL 0.4041 mL 0.8082 mL 2.0205 mL
25 mM 0.0647 mL 0.3233 mL 0.6466 mL 1.6164 mL
30 mM 0.0539 mL 0.2694 mL 0.5388 mL 1.3470 mL
40 mM 0.0404 mL 0.2021 mL 0.4041 mL 1.0103 mL
50 mM 0.0323 mL 0.1616 mL 0.3233 mL 0.8082 mL
60 mM 0.0269 mL 0.1347 mL 0.2694 mL 0.6735 mL
80 mM 0.0202 mL 0.1010 mL 0.2021 mL 0.5051 mL
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XMU-MP-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XMU-MP-22031152-10-8BRKBreast tumor kinaseProtein tyrosine kinase 6 (PTK6)Inhibitorinhibitorinhibit

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