2. Signaling Pathways
  3. Apoptosis
  4. Bcl-2 Family
  5. Bcl-2 Family Isoform
  6. Bcl-2 Family Antagonist

Bcl-2 Family Antagonist

Bcl-2 Family Antagonists (4):

Cat. No. Product Name Effect Purity
  • HY-12908
    Bcl-xL antagonist 2
    		Antagonist 98.86%
    Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of BCL-XL with an IC50 and Ki of 0.091 μM and 65 nM, respectively. Bcl-xL antagonist 2 promotes the apoptosis of cancer cells. Bcl-xL antagonist 2 has the potential for the research of the chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL).
  • HY-130261
    Mcl-1 antagonist 1
    		Antagonist
    Mcl-1 antagonist 1 is a Mcl-1 protein antagonist extracted from patent WO2019173181, compound 200.
  • HY-123020
    CYD-2-88
    		Antagonist
    CYD-2-88 (BDA-366 analog) is a BDA-366 (HY-101083) (Bcl2 BH4 antagonist) analog. CYD-2-88 (20 mg/kg, i.p.) inhibits tumor growth in NSCLC H460 xenografts mice.
  • HY-13407R
    Gossypol (Standard)
    		Antagonist
    Gossypol (Standard) is the analytical standard of Gossypol. This product is intended for research and analytical applications. Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.