Bcl-xL antagonist 2

Name: Bcl-xL antagonist 2
Brand: MedChemExpress
SKU: HY-12908
Rating: 4.5 (1 reviews)

Cat. No.: HY-12908 Purity: 98.86%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of BCL-X_L with an IC₅₀ and K_i of 0.091 μM and 65 nM, respectively. Bcl-xL antagonist 2 promotes the apoptosis of cancer cells. Bcl-xL antagonist 2 has the potential for the research of the chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL).

For research use only. We do not sell to patients.

Bcl-xL antagonist 2 Chemical Structure

CAS No. : 1235032-75-3

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 407	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 407	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 370	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 555	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 999	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1398	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1820	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

0.091 μM (BCL-X_L)^[1]

In Vivo

Assessment of Pharmacokinetics (PK) profile of Bcl-xL antagonist 2 (compound 14) in rat^[1].

iv (1 mg/kg)			po (5 mg/kg)
CL_p (mL/min/kg)	V_ss (L/kg)	t 1/2 (h)	F %
0.47	0.16	6.0	16

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

436.51

Formula

C₂₁H₁₆N₄O₃S₂

CAS No.

1235032-75-3

Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C(C1=C(CN(C2=NC(C(O)=O)=CS2)CC3)C3=CC=C1)NC4=NC5=C(S4)C=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (143.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2909 mL	11.4545 mL	22.9090 mL
5 mM	0.4582 mL	2.2909 mL	4.5818 mL
10 mM	0.2291 mL	1.1454 mL	2.2909 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 6.25 mg/mL (14.32 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.86%

Select Batch:

Data Sheet (289 KB) SDS (251 KB)

COA (256 KB) RP-HPLC (252 KB)

Handling Instructions (2659 KB)

References

[1]. Koehler MF, et al. Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL. ACS Med Chem Lett. 2014;5(6):662-667. [Content Brief]

[2]. Wang L, et al. Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor. ACS Med Chem Lett. 2020;11(10):1829-1836. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2909 mL	11.4545 mL	22.9090 mL	57.2725 mL
	5 mM	0.4582 mL	2.2909 mL	4.5818 mL	11.4545 mL
	10 mM	0.2291 mL	1.1454 mL	2.2909 mL	5.7272 mL
	15 mM	0.1527 mL	0.7636 mL	1.5273 mL	3.8182 mL
	20 mM	0.1145 mL	0.5727 mL	1.1454 mL	2.8636 mL
	25 mM	0.0916 mL	0.4582 mL	0.9164 mL	2.2909 mL
	30 mM	0.0764 mL	0.3818 mL	0.7636 mL	1.9091 mL
	40 mM	0.0573 mL	0.2864 mL	0.5727 mL	1.4318 mL
	50 mM	0.0458 mL	0.2291 mL	0.4582 mL	1.1454 mL
	60 mM	0.0382 mL	0.1909 mL	0.3818 mL	0.9545 mL
	80 mM	0.0286 mL	0.1432 mL	0.2864 mL	0.7159 mL
	100 mM	0.0229 mL	0.1145 mL	0.2291 mL	0.5727 mL