Bcl-2 Family Inhibitor

Bcl-2 Family Inhibitors (319):

Cat. No.	Product Name	Effect	Purity

HY-159938

p38α inhibitor 6	Inhibitor
p38α inhibitor 6 (compound 19) is a p38α inhibitor with the IC₅₀ of 0.68 μM. p38α inhibitor 6 induces cell apoptosis and arrests cell cycle at G0 and G2/M phase. p38α inhibitor 6 decreases the TNF-α concentration as well as increased the expression of tumor suppressor gene p53, Bax/BCL-2 ratio and caspase 3/7.

HY-169124

Apoptosis inducer 28	Inhibitor
Apoptosis Inducer 28 (Compound X1) is an apoptosis-inducing agent with anticancer activity in vitro. Apoptosis Inducer 28 can arrest the cell cycle at the G1 phase, promote cell death, and induce apoptosis by disrupting mitochondrial membrane potential. Apoptosis inducer 28 can also decrease the production of reactive oxygen species, downregulate the gene expression of BAX, Bcl-xL, and Bcl-2, while upregulating the gene expression of PAR-4.

HY-169267

BRD-K44839765	Inhibitor
BRD-K44839765 is selective against Bcl-2 with an IC₅₀ value of 5.6 μM in IMR-90 cell. BRD-K44839765 has oral activity.

HY-RS01423

Bcl2l1 Rat Pre-designed siRNA Set A	Inhibitor
Bcl2l1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-163308

Bcl-2-IN-18	Inhibitor
Bcl-2-IN-18 (Compound 23) is a breast cancer Bcl-2 inhibitor with a IC₅₀ value of 4.7 μM for MCF-7. Bcl-2-IN-18 has antitumor activity.

HY-P990344

Anti-Bcl-2 Antibody	Inhibitor
The Anti-Bcl-2 Antibody is a humanized antibody expressed in CHO cells, targeting Bcl-2. The Anti-Bcl-2 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.74 kDa. The isotype control for Anti-Bcl-2 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-126741R

Azadirachtin (Standard)	Inhibitor
Azadirachtin (Standard) is the analytical standard of Azadirachtin. This product is intended for research and analytical applications. Azadirachtin, one of the most promising botanical insecticides, is widely used for pest control. Azadirachtin induces apoptosis in insect cell lines, including Sf9, SL-1 and BTI-Tn-5B1-4.

HY-173309

P53/TLR2 modulator-1	Inhibitor
P53/TLR2 modulator-1 (Compound Z9) is a modulator that targets both the P53 pathway and TLR2 simultaneously, exhibiting anti-radiation activity. P53/TLR2 modulator-1 reduces apoptosis by inhibiting the radiation-induced expression of P53 and Bax. At the same time, it activates the TLR2 pathway, upregulates the expression of downstream proteins MyD88 and P65, and promotes the secretion of cytokines such as IL-6, thus exerting an anti-radiation effect. P53/TLR2 modulator-1 shows significant anti-radiation activity against both AHH-1 cells and HUVECs. It can also increase the survival rate of C57BL/6J mice irradiated with a lethal dose of radiation and reduce the damage to their hematopoietic system, the villous structure of the small intestine, and the spleen caused by radiation. P53/TLR2 modulator-1 can be used in the research of radiation injury-related diseases.

HY-RS08231

Mcl1 Mouse Pre-designed siRNA Set A	Inhibitor
Mcl1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mcl1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-103271

Bax inhibitor peptide, negative control	Inhibitor
Bax inhibitor peptide, negative control is a inhibitor of Bax. Bax inhibitor peptide, negative control inhibits Bax translocation to mitochondria and Bax-mediated apoptosis in vitro.

HY-RS01427

BCL2L11 Human Pre-designed siRNA Set A	Inhibitor
BCL2L11 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01429

Bcl2l11 Rat Pre-designed siRNA Set A	Inhibitor
Bcl2l11 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-N3913

Furowanin A	Inhibitor
Furowanin A is a flavonoid with anti-neoplastic effects. Furowanin A inhibits STAT3/Mcl-1 axis to suppress proliferation, block cell cycle progression, induce apoptosis and promote autophagy. Furowanin A potently inhibits colorectal cancer (CRC) cells.

HY-N0281R

Daphnetin (Standard)	Inhibitor
Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research.

HY-N0087R

Gambogic Acid (Standard)	Inhibitor
Gambogic Acid (Standard) is the analytical standard of Gambogic Acid. This product is intended for research and analytical applications. Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-149623

Bcl-2-IN-13	Inhibitor
Bcl-2-IN-13 is a Bcl-2 inhibitor with an IC₅₀ value of 17 nM. Bcl-2-IN-13 can be used in cancer research.

HY-163764

Bfl-1-IN-4	Inhibitor
Bfl-1-IN-4 (Compound 8) is an inhibitor for Bcl-2 associated protein A1 (Bfl-1) with an IC₅₀ of 16.8 μM.

HY-12048R

Chelerythrine chloride (Standard)	Inhibitor
Chelerythrine (chloride) (Standard) is the analytical standard of Chelerythrine (chloride). This product is intended for research and analytical applications. Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC₅₀ of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.

HY-149625

Bcl-2-IN-15	Inhibitor
Bcl-2-IN-15 (Compound 13d)) is a Bcl-2 inhibitor (IC₅₀: 363 nM). Bcl-2-IN-15 inhibits the proliferation ofNCI leukemia cancer cell line.

HY-163309

Bcl-2-IN-19	Inhibitor
Bcl-2-IN-19 (compound 27) is a potent Bcl-2 inhibitor for targeting breast cancer.

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