2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. CDK
  5. CDK Isoform
  6. CDK Activator

CDK Activator

CDK Activator (1):

Cat. No. Product Name Effect Purity
  • HY-13661
    7-Hydroxystaurosporine
    		Activator
    7-Hydroxystaurosporine (UCN-01) is a synthetic derivative of Staurosporine (HY-15141) with antitumor activity. 7-hydroxystaurosporine inhibits serine/threonine kinase AKT and calcium-dependent protein kinase C activity. 7-hydroxystaurosporine also activates indirectly cyclin-dependent kinases (CDKs). 7-hydroxystaurosporine arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis.