2. Cell Cycle/DNA Damage
  3. CDK
  4. INK4C-IN-2

INK4C-IN-2 (Compound 40) is the inhibitor for INK4C (also known as p18) and the activator for CDK4/6. INK4C-IN-2 increases the number and expansion capacity of mouse and human hematopoietic stem cells (HSCs) with EC50 of 5.21 nM, promotes the self-renewal and multilineage differentiation of HSCs. INK4C-IN-2 improves the expansion and long-term hematopoietic reconstruction ability of HSCs in mouse bone marrow transplantation model.

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INK4C-IN-2 Chemical Structure

INK4C-IN-2 Chemical Structure

CAS No. : 6314-70-1

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Based on 1 publication(s) in Google Scholar

Other Forms of INK4C-IN-2:

INK4C-IN-2 Related Antibodies

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1 Publications Citing Use of MCE INK4C-IN-2

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Description

INK4C-IN-2 (Compound 40) is the inhibitor for INK4C (also known as p18) and the activator for CDK4/6. INK4C-IN-2 increases the number and expansion capacity of mouse and human hematopoietic stem cells (HSCs) with EC50 of 5.21 nM, promotes the self-renewal and multilineage differentiation of HSCs. INK4C-IN-2 improves the expansion and long-term hematopoietic reconstruction ability of HSCs in mouse bone marrow transplantation model[1].

Molecular Weight

283.34

Formula

C13H17NO4S
CAS No.
SMILES

O=C(O)C1=CC=C(S(=O)(NC2CCCCC2)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (882.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5293 mL 17.6466 mL 35.2933 mL
5 mM 0.7059 mL 3.5293 mL 7.0587 mL
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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5293 mL 17.6466 mL 35.2933 mL 88.2332 mL
5 mM 0.7059 mL 3.5293 mL 7.0587 mL 17.6466 mL
10 mM 0.3529 mL 1.7647 mL 3.5293 mL 8.8233 mL
15 mM 0.2353 mL 1.1764 mL 2.3529 mL 5.8822 mL
20 mM 0.1765 mL 0.8823 mL 1.7647 mL 4.4117 mL
25 mM 0.1412 mL 0.7059 mL 1.4117 mL 3.5293 mL
30 mM 0.1176 mL 0.5882 mL 1.1764 mL 2.9411 mL
40 mM 0.0882 mL 0.4412 mL 0.8823 mL 2.2058 mL
50 mM 0.0706 mL 0.3529 mL 0.7059 mL 1.7647 mL
60 mM 0.0588 mL 0.2941 mL 0.5882 mL 1.4706 mL
80 mM 0.0441 mL 0.2206 mL 0.4412 mL 1.1029 mL
100 mM 0.0353 mL 0.1765 mL 0.3529 mL 0.8823 mL
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INK4C-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

INK4C-IN-26314-70-1CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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