2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. CDK
  5. CDK4 Isoform
  6. CDK4 Degrader

CDK4 Degrader

CDK4 Degraders (4):

Cat. No. Product Name Effect Purity
  • HY-163786
    PROTAC CDK4/6 degrader 1
    		Degrader 98.88%
    PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader for CDK4 and CDK6 with DC50 of 10.5 and 2.5 nM. PROTAC CDK4/6 degrader 1 inhibits the proliferation of cell Jurkat (IC50 is 0.18 μM), arrests the cell cycle at G1 phase and induces apoptosis. (Pink: ligand for target protein YY173 (HY-163787); Black: linker (HY-163788); Blue: ligand for E3 ligase (HY-10984))
  • HY-168664
    CPD-39
    		Degrader
    CPD-39 is a potent and orally active CCND1 and CDK4 heterobifunctional PROTAC degrader. CPD-39 shows anti-proliferation. (Pink: ligand for target protein (HY-50767); black: linker (HY-20240); Blue: E3 ligase ligand (HY-168667)).
  • HY-163640
    CDK4 degrader 1
    		Degrader
    CDK4 degrader 1 (ML 1–71) is a molecular glue degrader that targets CDK4.
  • HY-168660
    CPD-10
    		Degrader
    CPD-10 is a potent CCND1 and CDK4 heterobifunctional PROTAC degrader. CPD-10 shows anti-proliferation. CPD-10 induces apoptosis. CPD-10 decreases the protein expression of cyclin D1, cyclin D 3, CDK4, P-Rb(5807/811) in a dose-dependent manner. (Pink: ligand for target protein (HY-50767); black: linker (HY-22391); Blue: E3 ligase ligand (HY-168667)).