2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. CDK
  5. CDK4 Isoform
  6. CDK4 Degrader

CDK4 Degrader

CDK4 Degraders (2):

Cat. No. Product Name Effect Purity
  • HY-163786
    PROTAC CDK4/6 degrader 1
    		Degrader 98.88%
    PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader for CDK4 and CDK6 with DC50 of 10.5 and 2.5 nM. PROTAC CDK4/6 degrader 1 inhibits the proliferation of cell Jurkat (IC50 is 0.18 μM), arrests the cell cycle at G1 phase and induces apoptosis. (Pink: ligand for target protein YY173 (HY-163787); Black: linker (HY-163788); Blue: ligand for E3 ligase (HY-10984))
  • HY-163640
    CDK4 degrader 1
    		Degrader
    CDK4 degrader 1 (ML 1–71) is a monovalent degrader targeting CDK4.