2. PROTAC Cell Cycle/DNA Damage Apoptosis
  3. PROTACs CDK Apoptosis
  4. PROTAC CDK4/6 degrader 1

PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader for CDK4 and CDK6 with DC50 of 10.5 and 2.5 nM. PROTAC CDK4/6 degrader 1 inhibits the proliferation of cell Jurkat (IC50 is 0.18 μM), arrests the cell cycle at G1 phase and induces apoptosis. (Pink: ligand for target protein YY173 (HY-163787); Black: linker (HY-163788); Blue: ligand for E3 ligase (HY-10984))

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PROTAC CDK4/6 degrader 1 Chemical Structure

PROTAC CDK4/6 degrader 1 Chemical Structure

CAS No. : 3025082-14-5

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1 mg USD 1090 In-stock
5 mg USD 2180 In-stock
10 mg USD 3270 In-stock
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Based on 1 publication(s) in Google Scholar

PROTAC CDK4/6 degrader 1 Related Antibodies

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Description

PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader for CDK4 and CDK6 with DC50 of 10.5 and 2.5 nM. PROTAC CDK4/6 degrader 1 inhibits the proliferation of cell Jurkat (IC50 is 0.18 μM), arrests the cell cycle at G1 phase and induces apoptosis. (Pink: ligand for target protein YY173 (HY-163787); Black: linker (HY-163788); Blue: ligand for E3 ligase (HY-10984))[1]

IC50 & Target

CDK4

10.5 nM (DC50)

CDK6

2.5 nM (DC50)

Molecular Weight

789.88

Formula

C41H47N11O6
CAS No.
Appearance

Solid

Color

Light yellow to orange

SMILES

O=C1N(C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)CCCCC(NCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)=O)=NC=C2N=C1)C8CCCC8
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (126.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2660 mL 6.3301 mL 12.6602 mL
5 mM 0.2532 mL 1.2660 mL 2.5320 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2660 mL 6.3301 mL 12.6602 mL 31.6504 mL
5 mM 0.2532 mL 1.2660 mL 2.5320 mL 6.3301 mL
10 mM 0.1266 mL 0.6330 mL 1.2660 mL 3.1650 mL
15 mM 0.0844 mL 0.4220 mL 0.8440 mL 2.1100 mL
20 mM 0.0633 mL 0.3165 mL 0.6330 mL 1.5825 mL
25 mM 0.0506 mL 0.2532 mL 0.5064 mL 1.2660 mL
30 mM 0.0422 mL 0.2110 mL 0.4220 mL 1.0550 mL
40 mM 0.0317 mL 0.1583 mL 0.3165 mL 0.7913 mL
50 mM 0.0253 mL 0.1266 mL 0.2532 mL 0.6330 mL
60 mM 0.0211 mL 0.1055 mL 0.2110 mL 0.5275 mL
80 mM 0.0158 mL 0.0791 mL 0.1583 mL 0.3956 mL
100 mM 0.0127 mL 0.0633 mL 0.1266 mL 0.3165 mL
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PROTAC CDK4/6 degrader 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC CDK4/6 degrader 13025082-14-5PROTACsCDKApoptosisCyclin dependent kinaseJurkatdualInhibitorinhibitorinhibit

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