2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. CDK
  5. CDK5 Isoform
  6. CDK5 Degrader

CDK5 Degrader

CDK5 Degraders (2):

Cat. No. Product Name Effect Purity
  • HY-155218
    TMX-2172
    		Degrader
    TMX-2172 is a PROTACs degrader for CDK2 and CDK5, with the IC50s of 6.5 and 6.8 nM, respectively. TMX-2172 plays an important role in cancer research (Blue: E3 ligase ligand (HY-W008352); Pink: target protein ligand (HY-170748); Black: linker (HY-151072)).
  • HY-164906
    TMX-2138
    		Degrader
    TMX-2138 is a CDKs PROTAC degrader, with IC50s of 8.7 nM, 10.9 nM, 7.0 nM and 25.7 nM for CDK1/cyclinB, CDK2/cyclinA, CDK5/p25 and CDK9/cyclinT1, respectively. TMX-2138 promotes ubiquitination and degradation of CDKs. TMX-2138 can be used for the research of ovarian cancer (Pink: CDKs ligand (HY-151071); Blue: E3 ligase CRBN ligand (HY-14658); Black: linker (HY-W008352)).