2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. CDK
  5. CDK7 Isoform
  6. CDK7 Degrader

CDK7 Degrader

CDK7 Degraders (3):

Cat. No. Product Name Effect Purity
  • HY-153278
    CDK7-IN-21
    		Degrader
    CDK7-IN-21 (compound A22) is a potent CDK7 inhibitor.
  • HY-162706
    BSJ-5-63
    		Degrader
    BSJ-5-63 is a potent CDK12, CDK7, CDK9 PROTAC degrader. BSJ-5-63 BSJ-5-63 decreases the protein expression of CDK12, CDK7, CDK9, RNAPII, Cyclin K. BSJ-5-63 decreases the mRNA expression of BRCA1, BRCA2. BSJ-5-63 shows anticancer activity and has the potential for the research of prostate cancer (Pink: ligand for target protein (HY-150948); black: linker (HY-W140827); Blue: E3 ligase ligand (HY-112078)).
  • HY-164906
    TMX-2138
    		Degrader
    TMX-2138 is a CDKs PROTAC degrader, with IC50s of 8.7 nM, 10.9 nM, 7.0 nM and 25.7 nM for CDK1/cyclinB, CDK2/cyclinA, CDK5/p25 and CDK9/cyclinT1, respectively. TMX-2138 promotes ubiquitination and degradation of CDKs. TMX-2138 can be used for the research of ovarian cancer (Pink: CDKs ligand (HY-151071); Blue: E3 ligase CRBN ligand (HY-14658); Black: linker (HY-W008352)).