2. Signaling Pathways
  3. Immunology/Inflammation
  4. COX
  5. COX Isoform
  6. COX Control

COX Control

COX Controls (7):

Cat. No. Product Name Effect Purity
  • HY-139589
    Zaloglanstat
    		Control 98.50%
    Zaloglanstat (ISC-27864; GRC-27864) is a selective, orally active microsomal mPGES-1 inhibitor. Zaloglanstat has an IC50 of 5 nM for human mPGES-1 without significant inhibitory effect on COX-1/2 (IC50 >10 μM). Zaloglanstat blocks the conversion of arachidonic acid metabolite prostaglandin PGH2 to prostaglandin PGE2, thereby inhibiting inflammation-related PGE2 overproduction and reducing inflammatory responses and pain. Zaloglanstat inhibits IL-1β-induced PGE2 release in A549 cells and human synovial fibroblasts in vitro. Zaloglanstat inhibits PGE2 release in pig and dog whole blood with IC50s ??of 161 nM and 154 nM, respectively. Zaloglanstat can be used in the study of asthma, osteoarthritis, and neurodegenerative diseases.
  • HY-W087194
    p-Ethylhydratropic acid
    		Control 99.60%
    p-Ethylhydratropic acid (compound 5b) is the impurity of Ibuprofen (HY-78131). Ibuprofen is a potent, orally active, selective COX-1 inhibitor.
  • HY-126027
    (+)-3-Carene
    		Control
    (+)-3-Carene, a bicyclic monoterpene, is one of the major components of the pine tree essential oils. (+)-3-Carene is a (+)-enantiomer of 3-Carene (HY-N6663).
  • HY-139433
    6-Hydroxy etodolac
    		Control
    6-Hydroxy etodolac (compound 2) is a metabolite of Etodolac (HY-76251). Etodolac is a non-steroidal anti-inflammatory compound and is a COX inhibitor.
  • HY-124351
    5'-Hydroxy meloxicam
    		Control
    5'-Hydroxy meloxicam is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) Meloxicam (HY-B0261).
  • HY-119469
    Aceclofenac ethyl ester
    		Control
    Aceclofenac ethyl ester is an impurity of Aceclofenac (HY-B0634).
  • HY-137160
    (±)-Ketoprofen glucuronide
    		Control
    (±)-Ketoprofen glucuronide is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) Ketoprofen (HY-B0227).