CX3CR1

CX3C chemokine receptor1; GPR13; fractalkine receptor

CX3C chemokine receptor1 (CX3CR1), also known as the fractalkine receptor or GPR13, is the specific receptor to the CX3CL1. As the name suggests, CX3CR1 binds the chemokine CX3CL1 (also called fractalkine (in humans) or neurotactin (in mouse) ). CX3CL1 is a member of the CX3C family and that has been detected on activated endothelial cells, smooth muscle cells (SMCs), macrophages and platelets. CX3CL1 is the only neuronal chemokine in the body with pro-inflammatory, anti-inflammatory and neuroprotective effects, and is involved in the development of numerous inflammatory pathologies including atherosclerosis, rheumatoid arthritis, or graft rejection.

CX3CR1 Related Products (4):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-13848

AZD8797		99.54%
AZD8797 (KAND567) is an allosteric non-competitive and orally active antagonist of the human CX3CR1 receptor; antagonizes CX3CR1 and CXCR2 with K_is of 3.9 and 2800 nM, respectively.

HY-123918

JMS-17-2		99.90%
JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC₅₀ of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells.

HY-107456

E6130		≥98.0%
E6130 is an orally active and highly selective CX3CR1 modulator, that may be effective for treatment of inflammatory bowel disease.

HY-123918A

JMS-17-2 hydrochloride
JMS-17-2 hydrochloride is a potent and selective CX3CR1 antagonist with an IC₅₀ of 0.32 nM. JMS-17-2 hydrochloride impairs metastatic seeding and colonization of breast cancer cells.

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