2. Metabolic Enzyme/Protease
  3. PCSK9
  4. Alirocumab

Alirocumab  (Synonyms: REGN 727; SAR 236553)

Cat. No.: HY-P9928 Purity: 97.00%
COA

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Alirocumab (REGN 727) is a human monoclonal antibody inhibitor of PCSK9. Alirocumab is a monoclonal antibody. Alirocumab has anti-inflammatory, antiangiogenic and antioxidant effects. Alirocumab can be used in the study of hypercholesterolemia.

For research use only. We do not sell to patients.

CAS No. : 1245916-14-6

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1 mg USD 450 In-stock
5 mg USD 1100 In-stock
10 mg USD 1750 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Alirocumab:

Alirocumab Related Antibodies

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1 Publications Citing Use of MCE Alirocumab

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Description

Alirocumab (REGN 727) is a human monoclonal antibody inhibitor of PCSK9. Alirocumab is a monoclonal antibody. Alirocumab has anti-inflammatory, antiangiogenic and antioxidant effects. Alirocumab can be used in the study of hypercholesterolemia[1][2][3][4][5].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Human
In Vitro

Alirocumab (0.01, 0.1, 1, 2 and 10 μM, 24-72 h) does not affect cell viability and function in hiPSC-CMs and hESC-CMs, and can be used to evaluate drug safety in lipid-lowering cardiovascular cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alirocumab Related Antibodies

Cell Viability Assay[3]

Cell Line: hiPSC-CMs, hESC-CMs
Concentration: 0.01, 0.1, 1, 2, 10 μM
Incubation Time: 24-72 h
Result: Exhibited normal cell viability and did not affect the level of LDH release.
In Vivo

Alirocumab (3 or 10 mg/kg, subcutaneous injection weekly for 18 weeks) inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin[4].
Alirocumab (10 mg/kg, intraperitoneal injection at day 0, 10, 20) inhibits PCSK9 in rats and improves systemic oxidative stress and hyperlipidemia in BDL-induced cirrhosis rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CETP mice model[4]
Dosage: 3 or 10 mg/kg
Administration: s.c.
Result: Decreased total cholesterol dose-dependently.
Increased hepatic LDL receptor protein levels but did not affect hepatic cholesterol and TG content.
Decreased atherosclerotic lesion size and improved plaque morphology.
Animal Model: Rat model (240-280 g) [5]
Dosage: 10 mg/kg
Administration: i.p.
Result: Elevated ammonia, total cholesterol, LDL and ox-LDL levels.
Decreased plasma levels of total cholesterol, LDL, and oxidative stress markers.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

OC(CO)COP(O)(O)=O.[Na].[Na]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation

Purity: 97.00%

COA (231 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Alirocumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alirocumab1245916-14-6REGN 727 SAR 236553REGN727REGN-727SAR236553SAR 236553SAR-236553PCSK9Proprotein convertase subtilisin/kexin type 9PraluentInhibitorhiPSC-CMshESC-CMsLDLCETP mice modelAnti-inflammatoryinhibitorinhibit

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