Dipeptidyl Peptidase Inhibitor

Dipeptidyl Peptidase Inhibitors (67):

Cat. No.	Product Name	Effect	Purity

HY-14293

NVP-DPP728 dihydrochloride	Inhibitor
NVP-DPP728 dihydrochloride is a potent, selective and orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with a K_i of 11 nM. NVP-DPP728 dihydrochloride can be used for the research of diabetes mellitus.

HY-N10362

Ellipyrone B	Inhibitor
Ellipyrone B, an antihyperglycemic γ-pyrone enclosed macrocyclic polyketide, shows inhibition potential against dipeptidyl peptidase-4 (IC₅₀=0.48 mM).

HY-156846

O-Benzoylhydroxylamine	Inhibitor
O-Benzoyl hydroxylamine is a DPP-IV inhibitor with anti-diabetic effects (WO2006034435A2).

HY-155961

Antidiabetic agent 2	Inhibitor
Antidiabetic agent 2 (Compound 56) is a glucose-uptake promoter. Antidiabetic agent 2 inhibits DPP-4, PTP-1B, α-amylase, and α-glucosidase with IC₅₀s of 0.036, 0.042, 0.241, 0.185 μM. Antidiabetic agent 2 decreases blood glucose levels.

HY-168621

DPP-4-IN-13	Inhibitor
DPP-4-IN-13 (compound 9i) is a competitive DPP4 inhibitor with the IC₅₀ of 9.25 μM and can be used for study of type 2 diabetes.

HY-103434

PK44	Inhibitor
PK44 (Compound 67) is a potent dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ value of 15.8 nM. PK44 is promising for research of diabetes.

HY-161428

ZINC000003015356	Inhibitor
ZINC000003015356 is a DPP4 inhibitor.

HY-111174R

Diprotin A (Standard)	Inhibitor

HY-16448R

Saxagliptin (hydrochloride) (Standard)	Inhibitor
Saxagliptin (hydrochloride) (Standard) is the analytical standard of Saxagliptin (hydrochloride). This product is intended for research and analytical applications. Saxagliptin hydrochloride (BMS-477118 hydrochloride) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin hydrochloride has the peotential for type 2 diabetes mellitus research.

HY-P4488

H-Pro-Pro-Gln-OH	Inhibitor
H-Pro-Pro-Gln-OH is a oligopeptide with excellent dipeptidyl peptidase-IV (DPP-IV) inhibitory activity.

HY-10285S

Saxagliptin-¹⁵N,d₂ Hydrochloride	Inhibitor
Saxagliptin-15N,d2 Hydrochloride (BMS-477118-15N,d2 Hydrochloride) is the ¹⁵N and deuterium labeled isotope of Saxagliptin (HY-10285). Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (K_i = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research.

HY-160073A

Florensocatib hydrate	Inhibitor
Florensocatib hydrate is a DPP1 inhibitor (IC₅₀: 1.6 nM). Florensocatib hydrate has good bioavailability and pharmacokinetic characteristics, and can be used for research of inflammatory disease.

HY-14291S2

Vildagliptin-¹³C₅,¹⁵N	Inhibitor
Vildagliptin-¹³C₅,¹⁵N (LAF237-¹³C₅,¹⁵N; NVP-LAF 237-¹³C₅,¹⁵N) is a ¹³C- and ¹⁵N-labeled Vildagliptin (HY-14291). Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity.

HY-125330

Denagliptin tosylate	Inhibitor
Denagliptin tosylate is the tosyate salt form of Denagliptin. Denagliptin tosylate is a small molecule dipeptidyl peptidase IV (DPP-4) inhibitor. It can be used in type 2 diabetes research.

HY-157390

DPP-4-IN-9	Inhibitor
DPP-4-IN-9 (compound 6l) is a potent inhibitor of dipeptidyl peptidase DPP-4 (IC₅₀: 8.22 nM). DPP-4-IN-9 has antihyperglycemic activity.

HY-120631A

BMS-538305 hydrochloride	Inhibitor
BMS-538305 hydrochloride is a potent and selective inhibitor of dipeptidyl peptidase IV (DPP-IV), exhibiting strong biological activity by forming a reversible covalent complex with the enzyme. BMS-538305 hydrochloride demonstrates its mechanism of action through the covalent attachment between the nitrile carbon of the inhibitor and the enzyme residue S630, as unveiled by the X-ray crystal structure analysis.

HY-110083

PK44 phosphate	Inhibitor
PK44 phosphate is a potent dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ value of 15.8 nM.

HY-123171

ASP8497	Inhibitor
ASP8497 is a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor that reduces blood glucose levels and increases plasma active GLP-1 and insulin levels without causing hypoglycemia in fasted normal mice. ASP8497 can be utilized for antihyperglycemic research.

HY-160073

Florensocatib	Inhibitor
Florensocatib (compound 1) is a potent inhibitor of DPP1. Florensocatib can used in study bronchiectasis.

HY-B0422R

Nateglinide (Standard)	Inhibitor
Nateglinide (Standard) is the analytical standard of Nateglinide. This product is intended for research and analytical applications. Nateglinide, a D-phenylalanine derivative, is an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. Nateglinide inhibits ATP-sensitive K⁺ channels in pancreatic β-cells. Nateglinide is used for the treatment of type 2 (non-insulin-dependent) diabetes mellitus.

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