2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Dipeptidyl Peptidase
  5. Dipeptidyl Peptidase Isoform
  6. Dipeptidyl Peptidase Inhibitor

Dipeptidyl Peptidase Inhibitor

Dipeptidyl Peptidase Inhibitors (67):

Cat. No. Product Name Effect Purity
  • HY-14292
    NVP-DPP728
    		Inhibitor
    NVP-DPP728 is a potent, reversible and nitrile-dependent dipeptidyl peptidase IV (DPP-IV) inhibitor. NVP-DPP728 can inhibit human DPP-IV amidolytic activity with a Ki of 11 nM. NVP-DPP728 inhibits degradation of glucagon-like peptide-1 (GLP-1) and thereby potentiates insulin release in response to glucose intake. NVP-DPP728 can be used for researching diabetes.
  • HY-15408S
    Trelagliptin-13C,d3
    		Inhibitor
    Trelagliptin-13C,d3 is a deuterated labeled Trelagliptin. Trelagliptin (SYR-472) is a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM. Trelagliptin succinate improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM).
  • HY-P991050
    Procizumab
    		Inhibitor
    Procizumab (AK-1967) is a humanized IgG1 antibody that targets dipeptidyl peptidase 3 (DPP3). Procizumab has the potential for the study of sepsis. The isotype control for Procizumab can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
  • HY-170657
    DPP-4-IN-14
    		Inhibitor
    DPP-4-IN-14 (compound 30) is a DPP-4 inhibitor, with an IC50 of 12.82 nM.
  • HY-N9725
    16-Hydroxycleroda-3,13-dien-15,16-olide
    		Inhibitor
    16-Hydroxycleroda-3,13-dien-15,16-olide (16ξ-Hydroxycleroda-3,13-dien-15,16-olide; HCD), a clerodane diterpene, is a potent serine protease dipeptidyl peptidase 4 (DPP-4) inhibitor. 16-Hydroxycleroda-3,13-dien-15,16-olide down-regulates LPS-induced ERK phosphorylation in myocyte but blocks GLP-1 induced PKA expression. 16-Hydroxycleroda-3,13-dien-15,16-olide exhibits hypolipidemic, hepatoprotective, hypoglycemic efficacy.
  • HY-163335
    MPO-IN-7
    		Inhibitor
    MPO-IN-7 (compound MDC) is a myeloperoxidase inhibitor with the IC50 values of 41 μM, 25 μM and 4.5 μM towards α-Glucosidase, dipeptidyl peptidase-4 and myeloperoxidase, respectively. MPO-IN-7 shows antioxidant and anti-inflammatory activity in vitro.
  • HY-10284S3
    Linagliptin-d3-1
    		Inhibitor
    Linagliptin-d3-1 (BI 1356-d3-1) is the deuterium labeled Linagliptin (HY-10284). Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.
  • HY-129736A
    P32/98
    		Inhibitor
    P32/98 a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model.
  • HY-15408AR
    Trelagliptin (succinate) (Standard)
    		Inhibitor
    Trelagliptin (succinate) (Standard) is the analytical standard of Trelagliptin (succinate). This product is intended for research and analytical applications. Trelagliptin (SYR-472) succinate is a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM. Trelagliptin succinate improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM).
  • HY-13749CR
    (S)-Sitagliptin (phosphate) (Standard)
    		Inhibitor
    (S)-Sitagliptin (phosphate) (Standard) is the analytical standard of (S)-Sitagliptin (phosphate). This product is intended for research and analytical applications. (S)-Sitagliptin phosphate is the less active S-enantiomer of Sitagliptin phosphate. Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts.
  • HY-14806R
    Teneligliptin (Standard)
    		Inhibitor
    Teneligliptin (Standard) is the analytical standard of Teneligliptin. This product is intended for research and analytical applications. Teneligliptin (MP-513) is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor. Teneligliptin competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM.
  • HY-N8134
    2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one
    		Inhibitor
    2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one is a natural product found in the leaves and stem bark of M. glabra. 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one displays binding affinities with dipeptidyl peptidase-4 (DPP-4) and α-Amylase. 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one has potential antidiabetic activities.
  • HY-14291R
    Vildagliptin (Standard)
    		Inhibitor
    Vildagliptin (Standard) is the analytical standard of Vildagliptin. This product is intended for research and analytical applications. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity.
  • HY-10285S1
    (rel)-Saxagliptin-13C,d2 TFA
    		Inhibitor
    (rel)-Saxagliptin-13C,d2 ((rel)-BMS-477118-13C,d2) TFA is 13C-labeled Saxagliptin (HY-10285).
  • HY-N14989A
    Fluostatin A sodium
    		Inhibitor
    Fluostatin A sodium is a dipeptidyl peptidaseIII inhibitor with an IC50 of 0.44 μg/mL. Fluostatin A can be extracted from Streptomyces sp. TA-3391.
  • HY-12733
    AZD5248
    		Inhibitor
    AZD5248 is a dipeptidyl peptidase 1 (DPP1) inhibitor that can be used for the research of chronic obstructive lung disease.
  • HY-13749S2
    Sitagliptin-d4
    		Inhibitor
    Sitagliptin-d4 (MK-0431-d4) is deuterium labeled Sitagliptin. Sitagliptin (MK-0431) is a potent and orally active inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts.
  • HY-N15181
    Fluostatin B
    		Inhibitor
    Fluostatin B is a dipeptidyl peptidase 3 (DPP-3) inhibitor with an IC50 value of 24 µg/mL. Fluostatin B is a fluorenone, which is found in Streptomyces.
  • HY-16656
    BMS-767778
    		Inhibitor
    BMS-767778 is a selective DPP4 inhibitor, with a Ki of 0.9 nM.
  • HY-10284R
    Linagliptin (Standard)
    		Inhibitor
    Linagliptin (Standard) is the analytical standard of Linagliptin. This product is intended for research and analytical applications. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.