1. Metabolic Enzyme/Protease
  2. Dipeptidyl Peptidase
  3. P32/98

P32/98 a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model.

For research use only. We do not sell to patients.

P32/98 Chemical Structure

P32/98 Chemical Structure

CAS No. : 136259-20-6

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Description

P32/98 a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model[1][2][3].

IC50 & Target

DPP4[1]

In Vitro

GLP-1 acts function of stimulation of glucose dependent insulin secretion and induction of satiety feelings, and DPPIV is the major renal catabolic pathway for GLP-1 in vivo[2].
P32/98 hemifumarate, together with 200 pM GLP-1, (10 μM; 3 h) shows no significant inhibition of sodium re-absorption in porcine proximal tubular cells[2].
P32/98 (10 μM; 96 h) does not influence the mRNA expression of GLP-1R, DPPIV, Na+/H+ exchanger isoform 3 (NHE3), sodium-dependent glucose transporter slc5a1, slc5a2 (SGLT1, 2)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[2]

Cell Line: Porcine proximal tubular cells
Concentration: 10 μM
Incubation Time: 96 hours
Result: Showed no toxic.
In Vivo

P32/98 (25 mg/kg; i.g.; once daily) long-time treatment significantly improves the glucose tolerance in Zucker diabetic fatty rats, a model of IGT (impaired glucose tolerance)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zucker diabetic fatty rat[2]
Dosage: 25 mg/kg
Administration: Oral gavage; once daily
Result: Significantly improved the glucose tolerance in Zucker diabetic fatty rats.
Molecular Weight

202.32

Formula

C9H18N2OS

CAS No.
SMILES

CC[C@H](C)[C@H](N)C(N1CSCC1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
P32/98
Cat. No.:
HY-129736A
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