2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W040268S1
    1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-d9
    1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-d9 is deuterium labeled 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine. 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine is a phospholipid that is a major component of the lipid bilayer that surrounds cells and provides stability to the membrane.
    1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-d<sub>9</sub>
  • HY-W015466S1
    Acetylvaline-13C2
    Acetylvaline-13C2 is the 13C-labeled Acetylvaline. Acetylvaline is an endogenous metabolite.
    Acetylvaline-<sup>13</sup>C<sub>2</sub>
  • HY-W744160
    Stigmasterol-d6
    Stigmasterol-d6 is deuterium-labeled Stigmasterol (HY-N0131).
    Stigmasterol-d<sub>6</sub>
  • HY-W654000
    Cyclic GMP-13C,15N2
    Cyclic GMP-13C,15N2 is 13C and 15N labeled Cyclic GMP. Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferon genes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators.
    Cyclic GMP-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-B0660S1
    Eicosapentaenoic acid 1,2,3,4,5-13C5
    Eicosapentaenoic acid 1,2,3,4,5-13C5 (EPA 1,2,3,4,5-13C, FA 20:5-13C5) is 13C labeled Eicosapentaenoic Acid. Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation.
    Eicosapentaenoic acid 1,2,3,4,5-<sup>13</sup>C<sub>5</sub>
  • HY-W555010
    Phosphoenolpyruvic acid monosodium
    Phosphoenolpyruvic acid (Phosphoenolpyruvate) monosodium is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid monosodium is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid monosodium also exhibits cytoprotective and anti-oxidative properties.
    Phosphoenolpyruvic acid monosodium
  • HY-129300
    Prosulfocarb
    Prosulfocarb is a herbicide with a rapidly growing use trend. Prosulfocarb is used in winter cereals to help address the problem of increasing biotic resistance of weeds to certain pesticides. Environmental and food effects of prosulfocarb have been observed, and its transfer pattern from target crops to non-target areas has been studied. The volatility effect of prosulfocarb is an important factor explaining the inefficiency of isolated area contamination and marginal protection against residue spread.
    Prosulfocarb
  • HY-168801
    13,14-Dihydro-15-keto-tetranor prostaglandin F1β
    13,14-Dihydro-15-keto-tetranor prostaglandin F1β is a major urinary metabolite of Prostaglandin E2 (HY-101952).
    13,14-Dihydro-15-keto-tetranor prostaglandin F1β
  • HY-127152
    Hippadine
    Hippadine (Pratorine) is an alkaloid, which can be isolated from the plant Crinum macowanii. Hippadine exhibits heart-rate lowering and blood-pressure lowering effects in rats models with spontaneously hypertensive.
    Hippadine
  • HY-17367S5
    Atazanavir-d24
    Atazanavir-d24 (BMS-232632-d24) is deuterium labeled Atazanavir. Atazanavir (BMS-232632) is a highly selective and orally active HIV-1 protease inhibitor . Atazanavir is a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death.
    Atazanavir-d<sub>24</sub>
  • HY-B0157AR
    Ketotifen (fumarate) (Standard)
    Ketotifen (fumarate) (Standard) is the analytical standard of Ketotifen (fumarate). This product is intended for research and analytical applications. Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention.
    Ketotifen (fumarate) (Standard)
  • HY-127139
    Eicosapentaenoyl Chloride
    Eicosapentaenoyl chloride is a derivative of eicosapentaenoic acid. It has been used in the synthesis of fatty acid conjugates to enhance lipophilicity and cell permeability of bioactive compounds such as (–)-epigallocatechin gallate and salicylic acid.
    Eicosapentaenoyl Chloride
  • HY-B0661R
    Tamsulosin (Standard)
    Tamsulosin (Standard) is the analytical standard of Tamsulosin. This product is intended for research and analytical applications. Tamsulosin ((R)-(-)-YM12617 free base) is an inhibitor of α1-adrenergic receptor. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth in animal models.
    Tamsulosin (Standard)
  • HY-W008582
    (Z)-Methyl heptadec-10-enoate
    (Z)-Methyl heptadec-10-enoate (Methyl cis-10-heptadecenoate; C17:1 methyl ester) is the ester form of cis-10-heptadecenoic acid. It is a minor fatty acid methyl ester (FAME) component of biodiesel.
    (Z)-Methyl heptadec-10-enoate
  • HY-W017113R
    2-Mercaptobenzothiazole (Standard)
    2-Mercaptobenzothiazole (Standard) is the analytical standard of 2-Mercaptobenzothiazole. This product is intended for research and analytical applications. 2-Mercaptobenzothiazole is an endogenous metabolite.
    2-Mercaptobenzothiazole (Standard)
  • HY-N15362
    5α-Pregnane-3β,17α,20α-triol
    5α-Pregnane-3β,17α,20α-triol is an endogenous steroid compound. 5α-Pregnane-3β,17α,20α-triol is the metabolite of Pregnenolone (HY-B0151) or Progesterone (HY-N0437). 5α-Pregnane-3β,17α,20α-triol is promising for research of the endocrine function of the placenta and the mechanisms related to steroid hormone metabolism during pregnancy.
    5α-Pregnane-3β,17α,20α-triol
  • HY-134110
    N-Methylarachidonamide
    Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N-methyl amide is an analog of anandamide that binds to the human central cannabinoid (CB1) receptor with a Ki of 60 nM. It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM.
    N-Methylarachidonamide
  • HY-B0131S
    Prostaglandin E1-d4
    Prostaglandin E1-d4 is the deuterium labeled Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases[1][2][3].
    Prostaglandin E1-d<sub>4</sub>
  • HY-W014504R
    2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid (Standard)
    2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid (Standard) is the analytical standard of 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid. This product is intended for research and analytical applications. 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid is an endogenous metabolite.
    2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid (Standard)
  • HY-113085R
    3-Hydroxyhippuric acid (Standard)
    3-Hydroxyhippuric acid (Standard) is the analytical standard of 3-Hydroxyhippuric acid. This product is intended for research and analytical applications. 3-Hydroxyhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids.
    3-Hydroxyhippuric acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity