Endothelin Receptor Antagonist

Endothelin Receptor Antagonists (37):

Cat. No.	Product Name	Effect	Purity

HY-A0013

Bosentan	Antagonist	99.98%
Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively.

HY-15403A

Atrasentan hydrochloride	Antagonist	99.87%
Atrasentan hydrochloride (ABT-627 hydrochloride) is a selective endothelin A receptor antagonist with an IC₅₀ of 0.0551 nM for ET_A.

HY-A0013A

Bosentan hydrate	Antagonist	99.85%
Bosentan hydrate is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively.

HY-A0013AR

Bosentan hydrate (Standard)	Antagonist
Bosentan (hydrate) (Standard) is the analytical standard of Bosentan (hydrate). This product is intended for research and analytical applications. Bosentan hydrate is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively.

HY-105829

Sulfatroxazole	Antagonist
Sulfatroxazole (Isosulfafurazole) (compound 12) is a selective antagonist of ETA receptor (IC₅₀=0.26 μM).

HY-101262

SB234551	Antagonist
SB234551 is a selective endothelin ETA receptor antagonist. SB234551 can be used in the study of stroke model.

HY-17621

Sparsentan	Antagonist	99.77%
Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with K_is of 0.8 and 9.3 nM, respectively.

HY-15403

Atrasentan	Antagonist	99.58%
Atrasentan (ABT-627) is an endothelin receptor antagonist with IC₅₀ of 0.0551 nM for ET_A.

HY-17352

Clazosentan	Antagonist	98.01%
Clazosentan (Ro 61-1790) is a selective endothelin A (ET_A) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction.

HY-15195

Avosentan	Antagonist	98.15%
Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist.

HY-121300

Kendomycin	Antagonist	98.00%
Kendomycin ((−)-TAN 2162) is a polyketide antibiotic with remarkable antibacterial and cancer cells cytotoxic activities. Kendomycin tends to be bacteriostatic rather than bactericidal and inhibits the growth of the methicillin-resistant Staphylococcus aureus (MRSA) strain COL at a low concentration (MIC of 5 μg/mL). Kendomycin is a potent antagonist of the endothelin receptor and a calcitonin receptor agonist which plays its role as an anti-osteoporotic agent.

HY-12378A

BQ-123 TFA	Antagonist
BQ-123 TFA is a potent and selective endothelin A (ETA) receptor antagonist with an IC₅₀ of 7.3 nM and a K_i of 25 nM. BQ-123 TFA inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension.

HY-114953

BMS-248360	Antagonist
BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ET_A) receptor, with K_is of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 displays hypertensive effects.

HY-119667

Enrasentan	Antagonist
Enrasentan (SB 217242) is an endothelin (ET) receptor antagonist. Enrasentan has antihypertensive effects.

HY-112264

ETA antagonist 1	Antagonist
ETA antagonist 1 is a ETA selective antagonist with an IC₅₀ of 0.08 μM.

HY-115417

Bosentan-d4	Antagonist
Bosentan-d4 is the deuterium labeled Bosentan. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively.

HY-123744

PD-156707	Antagonist	99.92%
PD-156707 is an orally active, nonpeptide and selective Endothelin-A receptor antagonist.

HY-P2057

PD 142893	Antagonist
PD 142893 is a endothelin-B receptor antagonist.

HY-P990089

Patecibart	Antagonist
Patecibart is a humanized immunoglobulin G4-kappa, anti-EDNRA monoclonal antibody. Patecibart is an endothelin receptor antagonist.

HY-17621S

Sparsentan-d₅	Antagonist
Sparsentan-d₅ is deuterium labeled Sparsentan. Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively[1].

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