2. Signaling Pathways
  3. Anti-infection
  4. Filovirus

Filovirus

Filovirus

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Filoviruses is amongst the most lethal of primate pathogens. Filoviruses cause lethal hemorrhagic fever in humans and nonhuman primates. The family Filoviridae includes two genera: Marburgvirus, comprising various strains of the Lake Victoria marburgvirus (MARV); and Ebolavirus (EBOVs), comprising four species including Sudan ebolavirus (SEBOV), Zaire ebolavirus (ZEBOV), Ivory Coast ebolavirus (CIEBOV), and Reston ebolavirus (REBOV); and a tentative species Bundibugyo ebolavirus (BEBOV).

The infections typically affect multiple organs in the body and are often accompanied by hemorrhage (bleeding). Once the virus has been transmitted from an animal host to a human, it can then spread through person-to-person contact.

Filovirus Isoform Specific Products:

Filovirus Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-139223
    pEBOV-IN-1
    		Inhibitor
    pEBOV-IN-1 (Comp 2) is a pEBOV inhibitor, with an EC50 value of 0.38 μM. pEBOV: pseudotyped Ebola virus.
    pEBOV-IN-1
  • HY-161956
    Antiviral agent 59
    		Inhibitor
    Antiviral agent 59 (compound 58) is an antiviral agent with selective and drug-like properties that inhibits a broad spectrum of filoviruses. Antiviral agent 59 exhibits low off-target activity and inhibition against replication-competent Ebola virus (EBOV), Sudan virus (SUDV), and Marburg virus (MARV/b>).
    Antiviral agent 59
  • HY-10221R
    Vorinostat (Standard)
    		Inhibitor
    Vorinostat (Standard) is the analytical standard of Vorinostat. This product is intended for research and analytical applications. Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC6 and HDAC7 (Class II) and HDAC11 (Class IV), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification.
    Vorinostat (Standard)
  • HY-170547
    DNA polymerase-IN-6
    		Inhibitor
    DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, and inhibits HCMV, HSV-1, HSV-2 and EBV with EC50s of 0.33, 1.9, 0.76 and 0.066 µM, respectively.
    DNA polymerase-IN-6
  • HY-170493
    Antiviral agent 66
    		Inhibitor
    Antiviral agent 66 (Compound 60) is the inhibitor for Filovirus, that inhibits pseudotyped virus of Ebola, Marburg, Zaire, Sudan, Bundibugyo, Reston and Tai Forest with EC50s of 0.16, 2.24, 0.16, 0.89, 0.21, 0.21 and 0.11 μM, respectively.
    Antiviral agent 66
  • HY-115848
    Antiviral agent 12
    		Inhibitor
    Antiviral agent 12 is a antiviral compound. Antiviral agent 12 inhibits Ebola virus entry into host cells by binding to surface glycoprotein, EC50 is 3.9 μM. Antiviral agent 12 can be used in the study of Ebola virus.
    Antiviral agent 12
  • HY-150756
    EBOV-GP-IN-1
    		Inhibitor
    EBOV-GP-IN-1 (Compound 28) is a potent Ebola entry inhibitor with an IC50 of 0.05 μM against Ebola virus envelope glycoprotein (EBOV-GP).
    EBOV-GP-IN-1
Filovirus Isoform Comparison

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