EBOV

Ebolavirus

EBOV Related Products (22):

Cat. No.	Product Name	Effect	Purity

HY-122571

Retro-2	Inhibitor	≥98.0%
Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC₅₀ of 12.2 µM in HeLa cells. Retro-2 induces cell autophagy.

HY-119293

K777	Inhibitor	99.77%
K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC₅₀ of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC₅₀ values of 0.68 nM and 0.87 nM, respectively.

HY-124042

K6PC-5	Inhibitor	99.85%
K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration and virus infection research.

HY-N4118

Cephaeline	Inhibitor	98.94%
Cephaeline ((-)-Cephaeline), a desmethyl analog of Emetine, is a phenolic alkaloid in Indian Ipecac roots isolated from the Cephaelis ipecacuanha. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections. Cephaeline is an inductor of histone H3 acetylation and an inhibitor of mucoepidermoid carcinoma cancer stem cells (MEC), which promotes ferroptosis by inhibiting NRF2 to exert anti-lung cancer efficacy.

HY-P99832

Cosfroviximab
Cosfroviximab (c13C6-FR1) is a mouse/human chimeric monoclonal antibody against Ebola virus glycoprotein (EBOV-GP).

HY-160877

EBOV-IN-2
EBOV-IN-2 (Compound 2) is an inhibitor of Ebola virus (EBOV) with IC₅₀ values of 0.37 μM and 2.54 μM against Ebola virus glycoprotein pseudotype virus (pEBOV) and African swine fever virus (ASFV), respectively.

HY-160881

EBOV-IN-6
EBOV-IN-6 (compound 19) is benzothiazepine compound. EBOV-IN-6 has anti-pEBOV activity with a IC₅₀ value of 10 μM.

HY-160883

EBOV-IN-8	Inhibitor
EBOV-IN-8 (Compound 30) inhibits *Ebola* pseudotyped virus (pEBOV) infection with an IC₅₀ of 62.1% at 10 μM.

HY-137498

EBOV/MARV-IN-1	Inhibitor	99.14%
EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV), with broad-spectrum activity (EC₅₀=0.31, and 0.82 µM, respectively) and low cytotoxicity (SI>100) in HeLa cells.

HY-P99343

Atoltivimab	Inhibitor	98.66%
Atoltivimab (REGN3470), or maftivimab/odesivimab (Inmazeb) is the first Food and agent Administration (FDA)-approved monoclonal antibody to target Zaire ebolavirus (EBOVs) infection.

HY-146813

EBOV/MARV-IN-2	Inhibitor
EBOV/MARV-IN-2 (compound 13) is an Ebolavirus (EBOV, IC₅₀=0.9 μM) and Marburg virus (MARV, IC₅₀=2.7 μM) inhibitor.

HY-146883

As-358	Inhibitor
As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC₅₀s of 47.5 μM and 3.7 μM.

HY-N2076

Cephaeline hydrochloride	Inhibitor
Cephaeline hydrochloride ((-)-Cephaeline hydrochloride) is a phenolic alkaloid in Indian Ipecac roots. Cephaeline hydrochloride exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections.

HY-146814

EBOV/MARV-IN-3	Inhibitor
EBOV/MARV-IN-3 (compound 32) is a potent EBOV and MARV inhibitor with IC₅₀ values of 0.5, 1.2 µM, respectively. EBOV/MARV-IN-3 binds to the hydrophobic pocket close to EBOV Y517. EBOV/MARV-IN-3 shows antiviral activity.

HY-160879

EBOV-IN-4	Inhibitor
EBOV-IN-4 (compound 12), a benzothiazepine, is a potent Ebola virus (EBOV) inhibitor with 64.9% inhibitory for EBOV-GP-pseudotype virus (pEBOV) with 10 μM. EBOV-IN-4 is inactive with ASFV.

HY-146883A

As-358 hydrochloride	Inhibitor
As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC₅₀s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety.

HY-160882

EBOV-IN-7
EBOV-IN-7 (compound 26) is an inhibitor of the Ebola virus EBOV with an IC₅₀ of 2.04 μM against EBOV-GP pseudotyped virus (pEBOV). EBOV-IN-7 has inhibitory effects on cancer cells and inhibits the EBOV-GPcl/NPC1 interaction.

HY-146815

CP19	Inhibitor
CP19, a histamine receptor antagonist, is an entry inhibitor against both Ebolavirus (EBOV) and Marburgvirus (MARV) with IC₅₀s of 3.4 μM and 29.5 μM, respectively. CP19 has SI values of 29.4 and 3.4 for EBOV and MARV, respectively. CP19 has antiviral activity.

HY-160878

EBOV-IN-3	Inhibitor
EBOV-IN-3 (compound 9) is benzothiazepine compound. EBOV-IN-6 has anti-pEBOV activity with a IC₅₀ value of 0.37 μM.

HY-161691

EBOV-IN-9	Inhibitor
EBOV-IN-9 (compound 2b) is Diphyllin derivative that blocks Ebola viral entry with an EC₅₀ of 40 nM. EBOV-IN-9 against EBOV-infected monocyte-derived macrophages with an EC₅₀ of 107 nM.

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