2. Signaling Pathways
  3. MAPK/ERK Pathway
  4. MAP3K
  5. ASK2 Isoform

ASK2

 

ASK2 Related Products (1):

Cat. No. Product Name Effect Purity
  • HY-152247
    DDO3711
    		Inhibitor
    DDO3711, a PP5-recruiting phosphatase recruitment chimeras (PHORCs), is formed by connecting a small molecular apoptosis signal-regulated kinase 1 (ASK1) inhibitor to a PP5 activator through a chemical linker. DDO3711 specifically inhibits ASK1 (IC50 =164.1 nM) not ASK2 (IC50>20 μM). DDO3711 significantly dephosphorylates p-ASK1T838 by recruiting PP5 and shows the ASK1-dependent antiproliferative activity. DDO3711 has anti-cancer activity and has the potential for abnormally phosphorylated oncoproteins research.