2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP

MMP

Matrix metalloproteinases

MMP

Related Products

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MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands and chemokine/cytokine inactivation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense. MMP-2 and MMP-9 are thought to be important in metastasis. MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Recent data suggests active role of MMPs in the pathogenesis of Aortic Aneurysm. Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a characteristic of acute and chronic cardiovascular diseases.

MMP Isoform Specific Products:

MMP Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14240
    PG 116800
    		Inhibitor 99.81%
    PG 116800 (PG 530742) is an orally avtive MMP inhibitor. PG 116800 has high affinity for MMP-2, -3, -8, -9, -13, and -14, while having substantially lower affinity for MMP-1 and -7. PG 116800 can be used for knee osteoarthritis research.
    PG 116800
  • HY-P990251
    Anti-Human/Mouse denatured collagen type-I Antibody (XL313)
    Anti-Human/Mouse denatured collagen type-I Antibody (XL313) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to human/mouse denatured collagen type-I.
    Anti-Human/Mouse denatured collagen type-I Antibody (XL313)
  • HY-110397G
    KP-457 (GMP)
    		Inhibitor
    KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.
    KP-457 (GMP)
  • HY-N0801
    Polygalacic acid
    		Inhibitor 98.92%
    Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex.
    Polygalacic acid
  • HY-NP117
    Highly purified Type II collagen, from human sternal cartilage
    Highly purified Type II collagen, from human sternal cartilage (Human Type II collagen, immunization grade) is an immune grade collagen derived from human sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type II collagen, from human sternal cartilage
  • HY-RS08558
    Mmp9 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mmp9 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp9 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp9 Mouse Pre-designed siRNA Set A
    Mmp9 Mouse Pre-designed siRNA Set A
  • HY-N1981R
    Triolein (Standard)
    		Inhibitor
    Triolein (Standard) is the analytical standard of Triolein. This product is intended for research and analytical applications. Triolein is a symmetric triacylglycerol that reduces upregulation of MMP-1 and has strong antioxidant and anti-inflammatory activities.
    Triolein (Standard)
  • HY-RS08555
    Mmp8 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mmp8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp8 Mouse Pre-designed siRNA Set A
    Mmp8 Mouse Pre-designed siRNA Set A
  • HY-RS08537
    MMP2 Human Pre-designed siRNA Set A
    		Inhibitor

    MMP2 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MMP2 Human Pre-designed siRNA Set A
    MMP2 Human Pre-designed siRNA Set A
  • HY-RS08557
    MMP9 Human Pre-designed siRNA Set A
    		Inhibitor

    MMP9 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MMP9 Human Pre-designed siRNA Set A
    MMP9 Human Pre-designed siRNA Set A
  • HY-13564A
    Batimastat sodium salt
    		Inhibitor
    Batimastat sodium salt is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.
    Batimastat sodium salt
  • HY-111186
    Flocoumafen
    		99.17%
    Flocoumafen (WL 108366) is an orally active vitamin K epoxide reductase inhibitor and a multi-target ligand, which includes prostaglandin F synthase, serum albumin, glucocorticoid receptor 2, and MMP-9. Flocoumafen is a second-generation anticoagulant rodenticide (ARs) with a half-life of 177.4 hours and has deadly anticoagulant effects.
    Flocoumafen
  • HY-P10174A
    ADAM-17 Substrate TFA
    		98.00%
    ADAM-17 Substrate is a fluorescent substrate of ADAM.
    ADAM-17 Substrate TFA
  • HY-12170B
    (R)-Prinomastat
    		Control 98.36%
    (R)-Prinomastat ((R)-AG3340) is the R-isomer of Prinomastat (HY-12170) (a MMP Inhibitor).
    (R)-Prinomastat
  • HY-116302
    MMP-9-IN-9
    		Inhibitor
    MMP-9-IN-9 (compound 4f) is a slective MMP-9 inhibitor with an IC50 of 5 nM. MMP-9-IN-9 shows selective for MMP-9 over MMP-1 and MMP-13. MMP-9-IN-9 shows strong anti-inflammatory and neuroprotective effects.
    MMP-9-IN-9
  • HY-W745164
    3,3′-Bisdemethylpinoresinol
    		Inhibitor 98.96%
    3,3′-Bisdemethylpinoresinol, lignin, is a nature product and has MMP-1 inhibitory activity in UVA-irradiated human dermal fibroblasts. 3,3′-Bisdemethylpinoresinol can be isolated from the seeds of Morinda citrifolia.
    3,3′-Bisdemethylpinoresinol
  • HY-161169
    TP0628103
    		Inhibitor
    TP0628103 (compound 18) is a selective inhibitor of MMP-7, with the IC50 value of 0.17 nM that plays an important role in cancer and fibrosis.
    TP0628103
  • HY-157138
    MMP-9-IN-8
    MMP-9-IN-8 (Compound 3) is an MMP-9 inhibitor with inhibitory activities of 42.16% and 58.28% at 10 μM and 50 μM concentrations, respectively. MMP-9-IN-8 has anti-cancer activity and can induce apoptosis in MCF-7 cells with an IC50 value of 23.42 μM.
    MMP-9-IN-8
  • HY-NP126
    Highly purified Type XI collagen, from porcine articular cartilage
    Highly purified Type XI collagen, from porcine articular cartilage (Porcine Type XI collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type XI collagen, from porcine articular cartilage
  • HY-NP106
    Highly purified Type XI collagen, from bovine articular cartilage
    Highly purified Type XI collagen, from bovine articular cartilage (Bovine Type XI collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type XI collagen, from bovine articular cartilage
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
MMP Isoform Comparison

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