2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP

MMP

Matrix metalloproteinases

MMP

Related Products

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MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands and chemokine/cytokine inactivation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense. MMP-2 and MMP-9 are thought to be important in metastasis. MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Recent data suggests active role of MMPs in the pathogenesis of Aortic Aneurysm. Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a characteristic of acute and chronic cardiovascular diseases.

MMP Isoform Specific Products:

MMP Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-RS08525
    MMP13 Human Pre-designed siRNA Set A
    		Inhibitor

    MMP13 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MMP13 Human Pre-designed siRNA Set A
    MMP13 Human Pre-designed siRNA Set A
  • HY-RS08528
    MMP14 Human Pre-designed siRNA Set A
    		Inhibitor

    MMP14 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MMP14 Human Pre-designed siRNA Set A
    MMP14 Human Pre-designed siRNA Set A
  • HY-P10679
    GPLGLAGGWGERDGS
    GPLGLAGGWGERDGS is a peptide with MMP enzyme responsiveness and tumor targeting function, which can be used to monitor enzyme-guided nanoparticle assembly in tumors.
    GPLGLAGGWGERDGS
  • HY-RS08548
    MMP3 Human Pre-designed siRNA Set A
    		Inhibitor

    MMP3 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MMP3 Human Pre-designed siRNA Set A
    MMP3 Human Pre-designed siRNA Set A
  • HY-107013
    CP-544439
    		Inhibitor
    CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM.
    CP-544439
  • HY-115351
    GW-3333
    		Inhibitor
    GW-3333 is a potent and orally active TNF-alpha-converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitor. GW-3333 inhibits tumor necrosis factor-alpha (TNF-alpha) production. GW-3333 can be used in research of arthritis.
    GW-3333
  • HY-N2350R
    Cynaropicrin (Standard)
    		Inhibitor
    Cynaropicrin (Standard) is the analytical standard of Cynaropicrin. This product is intended for research and analytical applications. Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.
    Cynaropicrin (Standard)
  • HY-114091A
    PF-00356231
    		Inhibitor
    PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively.
    PF-00356231
  • HY-118672
    HNHA
    		Inhibitor 99.76%
    HNHA is a potent histone deacetylase (HDAC) inhibitor. HNHA arrests the cell cycle at the G1/S phase via p21 induction. HNHA inhibits tumor growth and tumor neovascularization. HNHA may be a potent anti-cancer agent against breast cancer.
    HNHA
  • HY-15182
    Collagen proline hydroxylase inhibitor-1
    Collagen proline hydroxylase inhibitor-1 is an antifibroproliferative agents.
    Collagen proline hydroxylase inhibitor-1
  • HY-B0149R
    Tranexamic acid (Standard)
    Tranexamic acid (Standard) is the analytical standard of Tranexamic acid. This product is intended for research and analytical applications. Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis .
    Tranexamic acid (Standard)
  • HY-RS08549
    Mmp3 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mmp3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp3 Mouse Pre-designed siRNA Set A
    Mmp3 Mouse Pre-designed siRNA Set A
  • HY-152030
    Tubulin/MMP-IN-2
    		Inhibitor
    Tubulin/MMP-IN-2 is dual inhibitor of tubulin and matrix metalloproteinases. Tubulin/MMP-IN-2 can strongly inhibit tubulin polymerization and induces cell apoptosis. Tubulin/MMP-IN-2 has inhibitory activities against MMP-2, MMP-3 and MMP-9 with IC50 values of 24.95 μM, 31.60 μM and 22.37 μM, respectively. Tubulin/MMP-IN-2 can be used for the research of cancer.
    Tubulin/MMP-IN-2
  • HY-142941
    Glucocorticoid receptor-IN-1
    		Inhibitor
    Glucocorticoid receptor-IN-1 (Compound WX002) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-1 exhibits very good transcriptional repressive activity with an IC50 of 2.11 nM against hMMP1, and transcriptional activation activity with an EC50 of 5.59 nM against MMTV.
    Glucocorticoid receptor-IN-1
  • HY-N0035R
    Arctigenin (Standard)
    		Inhibitor
    Arctigenin (Standard) is the analytical standard of Arctigenin. This product is intended for research and analytical applications. Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions.
    Arctigenin (Standard)
  • HY-RS00273
    Adam17 Rat Pre-designed siRNA Set A
    		Inhibitor

    Adam17 Rat Pre-designed siRNA Set A contains three designed siRNAs for Adam17 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Adam17 Rat Pre-designed siRNA Set A
    Adam17 Rat Pre-designed siRNA Set A
  • HY-N0131S1
    Stigmasterol-d5-1
    Stigmasterol-d5-1 is deuterium labeled Stigmasterol. Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases[1].
    Stigmasterol-d<sub>5</sub>-1
  • HY-RS08551
    MMP7 Human Pre-designed siRNA Set A
    		Inhibitor

    MMP7 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MMP7 Human Pre-designed siRNA Set A
    MMP7 Human Pre-designed siRNA Set A
  • HY-P4574
    VPLSLYSG
    VPLSLYSG is an octapeptide that can be degraded by matrix metalloproteinase-9 (MMP-9), MMP-1 and MMP-2. VPLSLYSG has potential applications in MMP substrates.
    VPLSLYSG
  • HY-RS00265
    ADAM10 Human Pre-designed siRNA Set A
    		Inhibitor

    ADAM10 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    ADAM10 Human Pre-designed siRNA Set A
    ADAM10 Human Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
MMP Isoform Comparison

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