2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP

MMP

Matrix metalloproteinases

MMP

Related Products

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MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands and chemokine/cytokine inactivation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense. MMP-2 and MMP-9 are thought to be important in metastasis. MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Recent data suggests active role of MMPs in the pathogenesis of Aortic Aneurysm. Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a characteristic of acute and chronic cardiovascular diseases.

MMP Isoform Specific Products:

MMP Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-155554
    SCAL-255
    		Inhibitor 99.15%
    SCAL-255 is a potent mitochondrial complex I (CI) inhibitor with an IC50 of 1.14 μM. SCAL-255 blocks mitochondrial function, inhibits oxygen consumption rate (OCR), induces reactive oxygen species (ROS) production, and reduces MMP. SCAL-255 can be used in the research of oxidative phosphorylation (OXPHOS)-dependent cancers, such as colorectal cancer (CRC) and acute myeloid leukemia (AML), etc.
    SCAL-255
  • HY-RS00266
    Adam10 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Adam10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adam10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Adam10 Mouse Pre-designed siRNA Set A
  • HY-B0149R
    Tranexamic acid (Standard)
    Tranexamic acid (Standard) is the analytical standard of Tranexamic acid. This product is intended for research and analytical applications. Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis .
    Tranexamic acid (Standard)
  • HY-RS00265
    ADAM10 Human Pre-designed siRNA Set A
    		Inhibitor

    ADAM10 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    ADAM10 Human Pre-designed siRNA Set A
  • HY-130391
    MMP12-IN-3
    		Inhibitor ≥99.0%
    MMP12-IN-3 (compound 32) is a potent MMP12 inhibitor with an IC50 value of 4.9 nM. MMP12-IN-3 has the potential for the research of chronic respiratory diseases such as emphysema.
    MMP12-IN-3
  • HY-P1789A
    CTTHWGFTLC, CYCLIC TFA
    		Inhibitor 98.91%
    CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC50 value for MMP-9 is ~8 μM.
    CTTHWGFTLC, CYCLIC TFA
  • HY-122106
    RS-104966
    		Inhibitor
    RS-104966 is a potent collagenase-1 (MMP-1) inhibitor. RS-104966 induces a conformational change in the side chains of the S10 pocket of MMP-1.
    RS-104966
  • HY-131417
    cis-ACCP
    		Inhibitor
    cis-ACCP is an orally active antimetastatic matrix metalloproteinase-2 (MMP-2) selective inhibitor. cis-ACCP can inhibit MMP-2 and MMP-9 with IC50 values of 4 μM and 20 μM, respectively. cis-ACCP can be used for the research of a variety of chronic diseases.
    cis-ACCP
  • HY-P5250
    Palmitoyl tripeptide-5
    		Inhibitor
    Palmitoyl tripeptide-5 is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient.
    Palmitoyl tripeptide-5
  • HY-N6860
    Lucidenic acid C
    		Inhibitor 99.76%
    Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells.
    Lucidenic acid C
  • HY-W010243
    Methylisothiazolinone hydrochloride
    		Inducer 99.40%
    Methylisothiazolinone hydrochloride is a bacterial and fungal inhibitor and preservative, as well as a sensitizer. Methylisothiazolinone hydrochloride can activate matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce apoptosis and inflammatory response. Methylisothiazolinone hydrochloride can promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses. Methylisothiazolinone hydrochloride can cause mitochondrial damage in the endothelium of rat cerebral blood vessels.
    Methylisothiazolinone hydrochloride
  • HY-110116
    SD-2590 hydrochloride
    		Inhibitor 99.1%
    SD-2590 hydrochloride is a potent MMP inhibitor with IC50 values of ﹤0.1, ﹤0.1, 0.18, and 1.7 nM for MMP2, MMP13, MMP9, and MMP8, respectively. SD-2590 hydrochloride inhibits dilation of the left ventricle in rats.
    SD-2590 hydrochloride
  • HY-149848
    MMP-9-IN-6
    		Inhibitor 99.80%
    MMP-9-IN-6 (Compound 3g) is a MMP-9 inhibitor with IC50 value of 50 μM, which has good anti-ulcer effect.
    MMP-9-IN-6
  • HY-P1912
    Alpha 1(I) Collagen (614-639), human
    		98.63%
    Alpha 1(I) Collagen (614-639), human is a peptide fragment of alpha-1 type I collagen.
    Alpha 1(I) Collagen (614-639), human
  • HY-163129
    BPU
    		99.04%
    BPU arrests cell cycle progression in the sub-G1 phase. BPU is an anticancer agent through inhibiting blood vessel formation in tumor tissues.
    BPU
  • HY-P4373
    Hepcidin-1 (mouse)
    		Inducer
    Hepcidin-1 (mouse) is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) facilitates osteoclast differentiation.
    Hepcidin-1 (mouse)
  • HY-14240
    PG 116800
    		Inhibitor 99.81%
    PG 116800 (PG 530742) is an orally avtive MMP inhibitor. PG 116800 has high affinity for MMP-2, -3, -8, -9, -13, and -14, while having substantially lower affinity for MMP-1 and -7. PG 116800 can be used for knee osteoarthritis research.
    PG 116800
  • HY-P10359A
    TAT-QFNP12 acetate
    		Inhibitor
    TAT-QFNP12 acetate is a peptide that blocks the NDRG2-PPM1A binding and reduces Smad2/3 phosphorylation, decreases astrocytic MMP-9 production and BBB disruption after subarachnoid hemorrhage (SAH).
    TAT-QFNP12 acetate
  • HY-P990251
    Anti-Human/Mouse denatured collagen type-I Antibody (XL313)
    Anti-Human/Mouse denatured collagen type-I Antibody (XL313) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to human/mouse denatured collagen type-I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) selectively binds to proteolyzed collagen type I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) reduces PD L1 levels in tumor cells. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) can be used for the researches of cancer and inflammation, such as such as ovarian tumor.
    Anti-Human/Mouse denatured collagen type-I Antibody (XL313)
  • HY-P11016
    PLGLAG
    		99.63%
    PLGLAG is a peptide chain that serves as a linker in activatable cell-penetrating peptides (ACPPs). ACPPs containing the linker PLGLAG are primarily responsive to MMP-2 and MMP-9 in vivo. PLGLAG can be used in cancer research.
    PLGLAG
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
MMP Isoform Comparison

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