2. Metabolic Enzyme/Protease
  3. Oxidative Phosphorylation Mitochondrial Metabolism
  4. SCAL-255

SCAL-255 is a potent mitochondrial complex I (CI) inhibitor with IC50 of 1.14 μM. SCAL-255 blocks mitochondrial function, inhibits OCR, induces ROS production, and reduces MMP. SCAL-255 displays a considerable antiproliferation effect against oxidative phosphorylation (OXPHOS)-dependent cancer cells.

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SCAL-255 Chemical Structure

SCAL-255 Chemical Structure

CAS No. : 2798953-61-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

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Description

SCAL-255 is a potent mitochondrial complex I (CI) inhibitor with IC50 of 1.14 μM. SCAL-255 blocks mitochondrial function, inhibits OCR, induces ROS production, and reduces MMP. SCAL-255 displays a considerable antiproliferation effect against oxidative phosphorylation (OXPHOS)-dependent cancer cells[1].

Molecular Weight

527.54

Formula

C27H28F3N5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NN(CC2=CC=CC(N3CCN(C(C4CC4)=O)CC3)=C2)C(C)=C1)NC5=CC=C(OC(F)(F)F)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (94.78 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8956 mL 9.4780 mL 18.9559 mL
5 mM 0.3791 mL 1.8956 mL 3.7912 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8956 mL 9.4780 mL 18.9559 mL 47.3898 mL
5 mM 0.3791 mL 1.8956 mL 3.7912 mL 9.4780 mL
10 mM 0.1896 mL 0.9478 mL 1.8956 mL 4.7390 mL
15 mM 0.1264 mL 0.6319 mL 1.2637 mL 3.1593 mL
20 mM 0.0948 mL 0.4739 mL 0.9478 mL 2.3695 mL
25 mM 0.0758 mL 0.3791 mL 0.7582 mL 1.8956 mL
30 mM 0.0632 mL 0.3159 mL 0.6319 mL 1.5797 mL
40 mM 0.0474 mL 0.2369 mL 0.4739 mL 1.1847 mL
50 mM 0.0379 mL 0.1896 mL 0.3791 mL 0.9478 mL
60 mM 0.0316 mL 0.1580 mL 0.3159 mL 0.7898 mL
80 mM 0.0237 mL 0.1185 mL 0.2369 mL 0.5924 mL
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SCAL-255 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCAL-2552798953-61-2SCAL255SCAL 255Oxidative PhosphorylationMitochondrial Metabolismmitochondrial complex ImitochondrialOCRROSMMP. SCAL-266antiproliferationoxidative phosphorylationOXPHOSInhibitorinhibitorinhibit

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