2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. Mps1

Mps1

Monopolar spindle 1

Mps1

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Monopolar spindle 1 (Mps1/TTK) is a serine/threonine kinase conserved from yeast to human. It has been shown to function as the key kinase that activates the spindle assembly checkpoint (SAC) to secure proper distribution of chromosomes to daughter cells.

MPS1, a dual specificity protein kinase, is also one of the main components of the SAC and ensures cells do not progress from metaphase to anaphase until the kinetochores are properly attached to the microtubules and under the appropriate tension at the metaphase plate. Cancer cells heavily rely on MPS1 to cope with aneuploidy resulting from aberrant numbers of chromosomes. The kinase has been found to be upregulated in a large number of tumor types. Mps1 is an attractive oncology target due to its high expression level in cancer cells as well as the correlation of its expression levels with histological grades of cancers.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12859
    BAY1217389
    		Inhibitor 99.94%
    BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM.
    BAY1217389
  • HY-14710
    AZ3146
    		Inhibitor 99.92%
    AZ3146 is a reasonably potent Mps1 and TTK inhibitor, with IC50 of 35 nM for Mps1Cat.
    AZ3146
  • HY-101340A
    Luvixasertib hydrochloride
    		Inhibitor 99.13%
    CFI-402257 hydrochloride is a highly selective and orally bioavailable TTK/Mps1 inhibitor with an IC50 of 1.7 nM for TTK in vitro. CFI-402257 hydrochloride has anti-cancer activity.
    Luvixasertib hydrochloride
  • HY-12382
    NMS-P715
    		Inhibitor 98.41%
    NMS-P715 is a selective, ATP-competitive inhibitor of MPS1, with an IC50 of 182 nM.
    NMS-P715
  • HY-12660
    MPI-0479605
    		Inhibitor 99.51%
    MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC50 of 1.8 nM.
    MPI-0479605
  • HY-164501
    Mps-BAY1
    		Inhibitor
    Mps-BAY1 is an MPS1 inhibitor with anticancer activity. Mps-BAY1 inhibits cell proliferation and induces apoptosis by activating mitotic catastrophe in cancer cells, generating global aneuploidy and polyploidy. Mps-BAY1 can be used in the study of colorectal cancer and cervical cancer.
    Mps-BAY1
  • HY-164518
    PF-3837
    		Inhibitor
    PF-3837 is an Mps1 kinase inhibitor with a Ki value of 0.33 nM and an IC50 value of 5.5 nM. PF-3837 interferes with the cell cycle checkpoint by inhibiting Mps1 catalytic activity, reducing genomic stability, thereby inducing cancer cell apoptosis (Apoptosis). PF-3837 can be used in research on breast cancer.
    PF-3837
  • HY-164516
    ONCOII
    		Inhibitor
    ONCOII is an Mps1 inhibitor with an IC50 of 10.8 nM. The inhibitory activity of ONCOII against Mps1 is affected by naturally occurring mutations in the Mps1 gene, and cells with Mps1 mutations exhibit increased resistance to ONCOII. ONCOII can be used in cancer research.
    ONCOII
  • HY-12858
    Empesertib
    		Inhibitor 98.82%
    Empesertib (BAY 1161909) is a potent Mps1 inhibitor, with an IC50 of < 1 nM.
    Empesertib
  • HY-112162
    BOS-172722
    		Inhibitor 98.65%
    BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer.
    BOS-172722
  • HY-13298
    Mps1-IN-1
    		Inhibitor 99.77%
    Mps1-IN-1 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 367 nM and 27 nM.
    Mps1-IN-1
  • HY-13994
    Mps1-IN-2
    		Inhibitor 98.04%
    Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC50 and a Kd of 145 nM and 12 nM for Mps1 and a Kd of 61 nM for Plk1.
    Mps1-IN-2
  • HY-12401
    Mps1-IN-3
    		Inhibitor 99.67%
    Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC50 of 50 nM.
    Mps1-IN-3
  • HY-110242
    Mps-BAY2a
    		Inhibitor 98.74%
    Mps-BAY2a is a monopolar spindle 1 (MPS1) inhibitor with an IC50 of 1 nM against human MPS1. Mps-BAY2a induces mitotic aberrations and apoptosis in cancer cells.
    Mps-BAY2a
  • HY-12862
    Mps1-IN-7
    		Inhibitor 98.55%
    Mps1-IN-7 is a potent MPS1 inhibitor (IC50 of 0.020 μM) over JNK1 and JNK2 (JNK1 IC50= 0.11 μM, JNK2 IC50=0.22 μM). Mps1-IN-7 inhibit SW620, CAL51, Miapaca-2, RMG1 cell growth with GI50 values of 0.065, 0.068, 0.25, and 0.110 μM,respectively.
    Mps1-IN-7
  • HY-12603
    CCT251455
    		Inhibitor 99.10%
    CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 (MPS1) inhibitor with an IC50 of 3 nM.
    CCT251455
  • HY-144308
    RMS-07
    		Inhibitor
    RMS-07 is a covalent Monopolar Spindle Kinase 1 (MPS1/TTK) inhibitor, with an apparent IC50 of 13.1 nM. RMS-07 targets a poorly conserved cysteine in the kinase's hinge region.
    RMS-07
  • HY-110115
    TC-Mps1-12
    		Inhibitor ≥99.0%
    TC-Mps1-12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor, with an IC50 of 6.4 nM.
    TC-Mps1-12
  • HY-12401A
    Mps1-IN-3 hydrochloride
    		Inhibitor 98.06%
    Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model.
    Mps1-IN-3 hydrochloride
  • HY-151980
    Mps1-IN-5
    		Inhibitor
    Mps1-IN-5 is a potent and orally active Mps1 inhibitor with an IC50 value of 29 nM. Mps1-IN-5 induces Apoptosis and cell cycle arrests at G2/M phase. Mps1-IN-5 shows antiproliferative activity and anti-tumor activity. Mps1-IN-5 inhibits phosphorylation of Mps1 and induces DNA damage.
    Mps1-IN-5
Cat. No. Product Name / Synonyms Application Reactivity