2. Cell Cycle/DNA Damage Cytoskeleton
  3. Mps1
  4. NTRC 0066-0

NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC50=0.9 nM). NTRC 0066-0 can be used for the research of cancer.

For research use only. We do not sell to patients.

NTRC 0066-0 Chemical Structure

NTRC 0066-0 Chemical Structure

CAS No. : 1817791-73-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 224 In-stock
Solution
10 mM * 1 mL in DMSO USD 224 In-stock
Solid
5 mg USD 180 In-stock
10 mg USD 290 In-stock
25 mg USD 580 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

NTRC 0066-0 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC50=0.9 nM). NTRC 0066-0 can be used for the research of cancer[1].

IC50 & Target

IC50: 0.9 nM (TTK)[1]
In Vitro

NTRC 0066-0 has a low selectivity entropy and a relatively long target residence time on TTK and inhibits the proliferation of diverse cancer cell lines with a potency in the same range as that of classic chemotherapeutic agents such as doxorubicin. NTRC 0066-0, has subnanomolar potency in a TTK enzyme assay and inhibits the proliferation of cancer cell lines from diverse tumor tissue origin with IC50 from 11 to 290 nM at 5-day incubation time[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NTRC 0066-0 Related Antibodies
In Vivo

NTRC 0066-0 inhibited tumor growth in a mouse xenograft model of the human triple-negative breast cancer (TNBC) cell line MDA-MB-231[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

565.71

Formula

C33H39N7O2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(C1=C2CCC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=C4OC)N=C3N2C=C1)NC6=C(CC)C=CC=C6CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (36.82 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7677 mL 8.8385 mL 17.6769 mL
5 mM 0.3535 mL 1.7677 mL 3.5354 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.01%

SDS (251 KB)

COA (248 KB) HNMR (141 KB) RP-HPLC (168 KB) LCMS (231 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7677 mL 8.8385 mL 17.6769 mL 44.1923 mL
5 mM 0.3535 mL 1.7677 mL 3.5354 mL 8.8385 mL
10 mM 0.1768 mL 0.8838 mL 1.7677 mL 4.4192 mL
15 mM 0.1178 mL 0.5892 mL 1.1785 mL 2.9462 mL
20 mM 0.0884 mL 0.4419 mL 0.8838 mL 2.2096 mL
25 mM 0.0707 mL 0.3535 mL 0.7071 mL 1.7677 mL
30 mM 0.0589 mL 0.2946 mL 0.5892 mL 1.4731 mL
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NTRC 0066-0 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NTRC 0066-01817791-73-3Mps1Monopolar spindle 1selectivityentropyrelativelylongtargetresidenceInhibitorinhibitorinhibit

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