Mps1-IN-7

Cat. No.: HY-12862 Purity: 98.55%: FAQs
Data Sheet SDS COA Handling Instructions

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Mps1-IN-7 is a potent MPS1 inhibitor (IC₅₀ of 0.020 μM) over JNK1 and JNK2 (JNK1 IC₅₀= 0.11 μM, JNK2 IC₅₀=0.22 μM). Mps1-IN-7 inhibit SW620, CAL51, Miapaca-2, RMG1 cell growth with GI₅₀ values of 0.065, 0.068, 0.25, and 0.110 μM,respectively.

For research use only. We do not sell to patients.

Mps1-IN-7 Chemical Structure

CAS No. : 1578244-34-4

Size	Price	Stock	Quantity
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 265	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 425	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 680	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
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Description

IC₅₀ & Target

IC50: 0.020 μM (MSP1)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CAL-27	GI₅₀	0.23 μM Compound: 34h	Antiproliferative activity against human CAL27 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human CAL27 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 27055065]
CAL-51	GI₅₀	0.068 μM Compound: 34h	Antiproliferative activity against human CAL51 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human CAL51 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 27055065]
HCT-116	IC₅₀	0.059 μM Compound: 34h	Inhibition of wild type Myc-ectopic MPS1 (unknown origin) expressed in human HCT116 cells assessed as autophosphorylation at Thr33/Ser37 after 2 hrs by electrochemiluminescence assay in presence of MG132 Inhibition of wild type Myc-ectopic MPS1 (unknown origin) expressed in human HCT116 cells assessed as autophosphorylation at Thr33/Ser37 after 2 hrs by electrochemiluminescence assay in presence of MG132	[PMID: 27055065]
HCT-116	GI₅₀	0.16 μM Compound: 34h	Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 27055065]
MIA PaCa-2	GI₅₀	0.25 μM Compound: 34h	Antiproliferative activity against human MIAPaCa2 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human MIAPaCa2 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 27055065]
PNT2	GI₅₀	3.95 μM Compound: 34h	Antiproliferative activity against human PNT2 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human PNT2 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 27055065]
RMG-I	GI₅₀	0.11 μM Compound: 34h	Antiproliferative activity against human RMG-1 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human RMG-1 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 27055065]
Sf9	IC₅₀	0.011 μM Compound: 34h	Inhibition of human full length MPS1 expressed in recombinant baculovirus infected Sf9 insect cells using 5FAM-DHTGFLTEYVATRCONH2 as substrate after 60 to 90 mins Inhibition of human full length MPS1 expressed in recombinant baculovirus infected Sf9 insect cells using 5FAM-DHTGFLTEYVATRCONH2 as substrate after 60 to 90 mins	[PMID: 27055065]
Sf9	IC₅₀	0.02 μM Compound: 34h	Inhibition of human full length MPS1 expressed in recombinant baculovirus infected Sf9 insect cells using 5FAM-DHTGFLTEYVATRCONH2 as substrate after 60 to 90 mins in presence of 1 mM ATP Inhibition of human full length MPS1 expressed in recombinant baculovirus infected Sf9 insect cells using 5FAM-DHTGFLTEYVATRCONH2 as substrate after 60 to 90 mins in presence of 1 mM ATP	[PMID: 27055065]
SW-620	GI₅₀	0.065 μM Compound: 34h	Antiproliferative activity against human SW620 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human SW620 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 27055065]

Molecular Weight

431.53

Formula

C₂₄H₂₉N₇O

CAS No.

1578244-34-4

Appearance

Solid

Color

White to yellow

SMILES

CC(C)(C)[C@@H](NC1=NC=CC2=CN=C(NC3=CC=C(C4=CN(C)N=C4)C=C3OC)N=C21)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (57.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3173 mL	11.5867 mL	23.1734 mL
5 mM	0.4635 mL	2.3173 mL	4.6347 mL
10 mM	0.2317 mL	1.1587 mL	2.3173 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.55%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (249 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Paolo Innocenti, et al. Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach. J Med Chem. 2016 Apr 28;59(8):3671-88 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3173 mL	11.5867 mL	23.1734 mL	57.9334 mL
	5 mM	0.4635 mL	2.3173 mL	4.6347 mL	11.5867 mL
	10 mM	0.2317 mL	1.1587 mL	2.3173 mL	5.7933 mL
	15 mM	0.1545 mL	0.7724 mL	1.5449 mL	3.8622 mL
	20 mM	0.1159 mL	0.5793 mL	1.1587 mL	2.8967 mL
	25 mM	0.0927 mL	0.4635 mL	0.9269 mL	2.3173 mL
	30 mM	0.0772 mL	0.3862 mL	0.7724 mL	1.9311 mL
	40 mM	0.0579 mL	0.2897 mL	0.5793 mL	1.4483 mL
	50 mM	0.0463 mL	0.2317 mL	0.4635 mL	1.1587 mL

Mps1-IN-7 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mps1-IN-71578244-34-4Mps1Monopolar spindle 1SW620CAL51Miapaca-2RMG1MPS1JNK2Inhibitorinhibitorinhibit

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Mps1-IN-7

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Complete Stock Solution Preparation Table

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