1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1741):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-138588
    7-TFA-ap-7-Deaza-ddA
    7-TFA-ap-7-Deaza-ddA (compound 19c, US20060281100A1), a nucleotide derivative, can be used in the synthesis of thiotriphosphate nucleotide dye terminators which can be used in DNA sequencing reactions.
    7-TFA-ap-7-Deaza-ddA
  • HY-152407
    7-Allyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl) guanine
    7-Allyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl) guanine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    7-Allyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl) guanine
  • HY-138616S2
    dGTP-15N5,d14 dilithium
    dGTP-15N5,d14 (2'-Deoxyguanosine-5'-triphosphate-15N5,d14) dilithium is deuterium and 15N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
    dGTP-<sup>15</sup>N<sub>5</sub>,d<sub>14</sub> dilithium
  • HY-152579
    6-(1-Piperazinyl)-9-β-D-ribofuranosyl-9H-purine
    6-(1-Piperazinyl)-9-β-D-ribofuranosyl-9H-purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    6-(1-Piperazinyl)-9-β-D-ribofuranosyl-9H-purine
  • HY-152325
    N1-(N,N-Dimethylaminocarbonyl)-pseudouridine
    N1-(N,N-Dimethylaminocarbonyl)-pseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N1-(N,N-Dimethylaminocarbonyl)-pseudouridine
  • HY-152418
    3’-Beta-C-Methyl-N6-(m-methoxybenzyl)adenosine
    3’-Beta-C-Methyl-N6-(m-methoxybenzyl)adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    3’-Beta-C-Methyl-N6-(m-methoxybenzyl)adenosine
  • HY-154275
    4’-Methylthymidine
    4’-Methylthymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    4’-Methylthymidine
  • HY-13640A
    Rabacfosadine succinate
    Rabacfosadine (GS-9219) succinate, a novel proagent of the nucleotide analogue PMEG, is designed as a cytotoxic agent that preferentially targets lymphoid cells.
    Rabacfosadine succinate
  • HY-152355
    N6-Methyl-xylo-adenosine
    N6-Methyl-xylo-adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    N6-Methyl-xylo-adenosine
  • HY-152415
    3’-Deoxy-3’-α-C-methyladenosine
    3’-Deoxy-3’-α-C-methyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-Deoxy-3’-α-C-methyladenosine
  • HY-112582A
    N1-Methylpseudouridine-5′-triphosphate
    N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability.
    N1-Methylpseudouridine-5′-triphosphate
  • HY-154082
    5-Caroxy uracil-1-yl acetic acid benzyl ester
    5-Caroxy uracil-1-yl acetic acid benzyl ester is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Caroxy uracil-1-yl acetic acid benzyl ester
  • HY-154542
    5’-O-Acetyl-2’,3’-dideoxy-2’,3’-didehydro-uridine
    5’-O-Acetyl-2’,3’-dideoxy-2’,3’-didehydro-uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5’-O-Acetyl-2’,3’-dideoxy-2’,3’-didehydro-uridine
  • HY-W048504
    1-[3’-O-[(4,4’-Dimethoxytriphenyl)methyl]-a-L-threofuranosyl]-N4-benzoylcytosine
    1-[3’-O-[(4,4’-Dimethoxytriphenyl)methyl]-a-L-threofuranosyl]-N4-benzoylcytosine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    1-[3’-O-[(4,4’-Dimethoxytriphenyl)methyl]-a-L-threofuranosyl]-N4-benzoylcytosine
  • HY-152993
    2′-Deoxy-N-(2-furanylmethyl)guanosine
    2′-Deoxy-N-(2-furanylmethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
    2′-Deoxy-N-(2-furanylmethyl)guanosine
  • HY-154060
    N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)adenosine
    N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)adenosine
  • HY-B1449S2
    Uridine-13C-1
    Uridine-13C-1 is the 13C labeled Uridine[1].
    Uridine-<sup>13</sup>C-1
  • HY-152338
    7-Propargyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine
    7-Propargyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 7-Propargyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    7-Propargyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine
  • HY-152390
    2’-Fluoro-2’-deoxy-N6-methylarabinoadenosine
    2’-Fluoro-2’-deoxy-N6-methylarabinoadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Fluoro-2’-deoxy-N6-methylarabinoadenosine
  • HY-160704
    CMX-521
    CMX-521, a nucleoside analog, is a potent inhibitor for RNA-dependant RNA polymerase (RdRp) of norovirus. CMX-521 suppresses murine norovirus (MNV) and human norovirus.
    CMX-521