2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1729):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W131753
    2'-F-Ac-C
    2'-F-Ac-C (N-Acetyl-2′-deoxy-2′-fluorocytidine) is a nucleoside analog that can be used to synthesize oligoribonucleotides.
    2'-F-Ac-C
  • HY-W653970
    5-Azacytidine-15N4
    5-Azacytidine-15N4 is 13C and 15N labeled 5-Azacytidine. 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes. 5-Azacytidine induces cell autophagy.
    5-Azacytidine-<sup>15</sup>N<sub>4</sub>
  • HY-134246
    7-CH-5'-dAMP
    7-CH-5'-dAMP (5'-dTuMP) is an adenylate derivative that acts as a potential substrate, competitive inhibitor, or modulator of enzymes that interact with 2-deoxyadenosine-5-monophosphate.
    7-CH-5'-dAMP
  • HY-47272A
    N6-Benzoyl-9-β-D-arabinofuranosyladenine hydrate
    N6-Benzoyl-9-β-D-arabinofuranosyladenine hydrate is the hydrate of N6-Benzoyl-9-β-D-arabinofuranosyladenine (HY-47272). N6-Benzoyl-9-β-D-arabinofuranosyladenine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    N6-Benzoyl-9-β-D-arabinofuranosyladenine hydrate
  • HY-B1449S12
    Uridine-d12
    Uridine-d12 (β-Uridine-d12) is the deuterium labeled Uridine (HY-B1449). Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond.
    Uridine-d<sub>12</sub>
  • HY-145976
    m7GpppGpG
    m7GpppGpG, an oligonucleotide, is an M7GpppNpG trinucleotide cap analogue. m7GpppGpG prevents premature degradation by 5′-exonucleases and recruits proteins required for pre-mRNA splicing, mRNA transport and initiation of protein biosynthesis.
    m7GpppGpG
  • HY-W881216
    (S)-GNA-T-phosphoramidite
    (S)-GNA-T-phosphoramidite (Compound 4) is a phosphoramidite compound that can be used for the synthesis of oligonucleotides.
    (S)-GNA-T-phosphoramidite
  • HY-113061R
    Pseudouridine (Standard)
    Pseudouridine (Standard) is the analytical standard of Pseudouridine. This product is intended for research and analytical applications. Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation[4].
    Pseudouridine (Standard)
  • HY-157504
    2′-O-Methyl-5′-O-phosphonoadenylyl-(3′→5′)-guanosine TEA
    2’-O-Methyl-5’-O-phosphonoadenylyl-(3’→5’)-guanosine (TEA) is a trinucleotide cap analogue that regulates protein expression in living cells.
    2′-O-Methyl-5′-O-phosphonoadenylyl-(3′→5′)-guanosine TEA
  • HY-W439487
    7,9-Dimethylguanine
    7,9-Dimethylguanine is a modified nucleotide base that is a product of RNA degradation. The level of 7,9-Dimethylguanine in urine and serum can be used as a scoring indicator for the severity of alcoholic liver disease (ALD).
    7,9-Dimethylguanine
  • HY-134382
    7-CH-dADP
    7-CH-dADP is a competitive inhibitor or regulator of enzymes that interact with dADP.
    7-CH-dADP
  • HY-W016011
    iBu-dG
    		≥98.0%
    iBu-dG (N2-Isobutyryl-2'-deoxyguanosine) is a nucleoside analog that can be used to synthesize oligoribonucleotides.
    iBu-dG
  • HY-152834
    8-Methoxyadenosine
    8-Methoxyadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    8-Methoxyadenosine
  • HY-Z15868
    5-Hydroxycytidine
    5-Hydroxycytidine is the RNA modified nucleoside that can be found in the 23S rRNA of bacteria E. coli. 5-Hydroxycytidine modifies at the C2501 site, exhibits a higher modification level in stationary cells. 5-Hydroxycytidine exhibits a higher modification level in radiation resistant Radius than in E. coli.
    5-Hydroxycytidine
  • HY-153061
    2’-O-Methylisocytidine
    2'-O-Methylisocytidine is a nucleoside compound.
    2’-O-Methylisocytidine
  • HY-134352
    AA-UTP tetrasodium
    AA-UTP tetrasodium is an amine-modified nucleotide that can be directly incorporated into labeled-UTP (HY-107372).
    AA-UTP tetrasodium
  • HY-D2361
    Adenosine 2'-PEG-Biotin
    Adenosine 2'-PEG-Biotin is a biochemical reagent derived from adenosine. Adenosine 2'-PEG-Biotin regulates cell signaling pathways by mimicking the effects of endogenous adenosine and binding to its receptors. Adenosine 2'-PEG-Biotin can be used in the research of bioprobes, biosensors and diagnostic reagents.
    Adenosine 2'-PEG-Biotin
  • HY-16445A
    CNDAC
    		Inhibitor
    CNDAC is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC induces DNA damage and apoptosis.
    CNDAC
  • HY-13701R
    Nelarabine (Standard)
    		Inhibitor
    Nelarabine (Standard) is the analytical standard of Nelarabine. This product is intended for research and analytical applications. Nelarabine (506U78) is a nucleoside analogue and can be used for the research of T cell acute lymphoblastic leukemia (T-ALL).
    Nelarabine (Standard)
  • HY-134314
    8-Nitro-cGMP
    8-Nitro-cGMP is an electrophilic second messenger of redox signaling that can form a protein-S-cGMP adduct in s-guanylation process. 8-Nitro-cGMP is an autophagy inducer. 8-Nitro-cGMP promotes RANKL-induced osteoclast differentiation from macrophages. 8-Nitro-cGMP has vasodilator effect, and ameliorates the vascular endothelial dysfunction in diabetic mice.
    8-Nitro-cGMP