2. Signaling Pathways
  3. Others
  4. Others
  5. Others Modulator

Others Modulator

Others Modulators (19):

Cat. No. Product Name Effect Purity
  • HY-120821
    Endosidin-2
    		Modulator 99.17%
    Endosidin2 (ES2) binds to the exocyst component of 70 kDa (EXO70) subunit of the exocyst complex with a Kd of 253 μM. Endosidin2 inhibits exocytosis and endosomal recycling in both plant and human cells and enhances plant vacuolar trafficking. Endosidin2 is a valuable new tool for the study of exocytosis.
  • HY-124634
    PZ-2891
    		Modulator 99.38%
    PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.
  • HY-147149
    BPN-15477
    		Modulator 99.80%
    BPN-15477 is a potent SMC (splicing modulator compound) that restores correct splicing of ELP1 (Elongator complex protein 1) exon 20. BPN-15477 corrects splicing of the ELP1 transcript, significantly increases the level of functional protein in vivo in all tissues, including brain. BPN-15477 can be used for frontotemporal dementia research.
  • HY-112920
    TM-25659
    		Modulator 99.33%
    TM-25659 is a transcriptional co-activator with PDZ-binding motif (TAZ) modulator. Anti-osteoporotic and anti-obesity activities.
  • HY-107661
    Arundic Acid
    		Modulator ≥98.0%
    Arundic acid (ONO-2506) is an astrocyte-modulating agent, which delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis. Arundic acid has the potential for stroke and Alzheimer’s disease research.
  • HY-135572
    TLX agonist 1
    		Modulator 99.94%
    TLX agonist 1 (ccrp2) is an orphan nuclear receptor tailless (TLX, NR2E1) modulator (EC50=1μM; Kd= 650 nM). TLX agonist 1 potentiates TLX transcriptional repressive activity.
  • HY-133021
    Arazine
    		Modulator ≥98.0%
    Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site.
  • HY-W012248
    KG-655
    		Modulator 99.87%
    KG-655 is a small molecule compound that binds to the β-folded surface and internal cavity of ARNT PAS-B and interferes with its binding to the transcriptional coactivator TACC3. KG-655 can promote the homodimerization of ARNT PAS-B and has the potential to regulate multiple ARNT-mediated signaling pathways.
  • HY-128128
    ASN04421891
    		Modulator 99.00%
    ASN04421891 is a potent GPR17 receptor modulator, with an EC50 of 3.67 nM in [35S]GTPγS binding assay. ASN04421891 can be used for neurodegenerative diseases research.
  • HY-134863
    A1AT modulator 2
    		Modulator 98.32%
    A1AT modulator 2 (compound 33) is a modulator of A1AT (α-1 antitrypsin) with an IC50 value of ＞1.0 μM and an EC50 value of ＜0.4 μM. A1AT modulator 2 can be used for the research of infection and inflammation.
  • HY-156645
    Tegomil fumarate
    		Modulator 99.72%
    Tegomil fumarate is an immunomodulator.
  • HY-W008769
    Ethychlozate
    		Modulator
    Ethychlozate is a plant growth regulator on the promotion of flowering in citrus.
  • HY-139564
    DOTA Zoledronate
    		Modulator
    DOTA Zoledronate is a next-generation agent for bone targeted radionuclide therapy for diagnosing bone metastases.
  • HY-153805
    Z-NCTS
    		Modulator
    Z-NCTS is an RNA mismatch binding molecule that recognizes the 5’-r(XGG)-3’/5’-r(XGG)-3’ sequence (X=U or A) and acts as a molecular glue for RNA.
  • HY-147367
    AM-1488
    		Modulator
    AM-1488 is a potent, orally active glycine receptor (GlyR) potentiator (hGlyRα3 EC50=0.45 μM).
  • HY-119698
    BAP9THP
    		Modulator 99.61%
    BAP9THP is a synthetic cytokinin derivative and a growth regulator. BAP9THP promotes chlorophyll retention (and senescence delay) in plant tissues exceptionally strongly, and growth of tobacco callus almost as strongly as 6-Benzylaminopurine (BAP). BAP9THP induces adventitious shoot formation ignificantly more strongly than N6-isopentenyladenine or Kinetin.
  • HY-163665
    AHR antagonist 8
    		Modulator
    AHR antagonist 8 (compound SG-02) is a regulator of utrophin, a homolog of dystrophin, and an AhR antagonist (Kd: 41.68 nM). Studies have shown that 800 nM of AHR antagonist 8 can upregulate utrophin by 2.7 times. AHR antagonist 8 also stimulates increased MyHC expression, suggesting that it has the potential to enhance myogenesis. After ADME evaluation, AHR antagonist 8 also has a certain oral bioavailability.
  • HY-158736
    Lyso-sulfatide (bovine) (ammonium)
    		Modulator
    Lyso-sulfatide (bovine) ammonium, a derivative of the glycosphingolipid sulfatide, acts as an extracellular signal regulating the migration of a neural precursor cell line (B35 neuroblastoma cells) by rapidly promoting process retraction and cell rounding.
  • HY-U00088
    3β,7β,17β-Trihydroxyandrost-5-ene
    		Modulator
    3b,7a,17a-Trihydroxyandrost-5-ene is a immune modulator extracted from patent US20030060425.