Others Modulator

Others Modulators (36):

Cat. No.	Product Name	Effect	Purity

HY-120821

Endosidin-2	Modulator	99.42%
Endosidin2 (ES2) binds to the exocyst component of 70 kDa (EXO70) subunit of the exocyst complex with a K_d of 253 μM. Endosidin2 inhibits exocytosis and endosomal recycling in both plant and human cells and enhances plant vacuolar trafficking. Endosidin2 is a valuable new tool for the study of exocytosis.

HY-124634

PZ-2891	Modulator	99.38%
PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC₅₀s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.

HY-147149

BPN-15477	Modulator	99.80%
BPN-15477 is a potent SMC (splicing modulator compound) that restores correct splicing of ELP1 (Elongator complex protein 1) exon 20. BPN-15477 corrects splicing of the ELP1 transcript, significantly increases the level of functional protein in vivo in all tissues, including brain. BPN-15477 can be used for frontotemporal dementia research.

HY-112103

6-(γ,γ-Dimethylallylamino)purine	Modulator	99.94%
6-(γ,γ-Dimethylallylamino)purine is a plant growth substance.

HY-107661

Arundic Acid	Modulator	≥98.0%
Arundic acid (ONO-2506) is an astrocyte-modulating agent, which delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis. Arundic acid has the potential for stroke and Alzheimer’s disease research.

HY-135572

TLX agonist 1	Modulator	99.94%
TLX agonist 1 (ccrp2) is an orphan nuclear receptor tailless (TLX, NR2E1) modulator (EC₅₀=1μM; K_d= 650 nM). TLX agonist 1 potentiates TLX transcriptional repressive activity.

HY-112920

TM-25659	Modulator	99.33%
TM-25659 is a transcriptional co-activator with PDZ-binding motif (TAZ) modulator. Anti-osteoporotic and anti-obesity activities.

HY-U00429

NOT Receptor Modulator 1	Modulator	98.61%
NOT Receptor Modulator 1 is a nuclear receptor NOT modulator extracted from patent WO 2008034974 A1, Example 39 in table1.

HY-153182

GBT1118	Modulator	99.19%
GBT1118 is a potent and orally active allosteric modifier of hemoglobin oxygen affinity. GBT1118 increases tolerance to severe hypoxia.

HY-157416

COP1-ATGL modulator 1	Modulator	99.31%
COP1-ATGL modulator 1 (86) is an orally active modulator for COP1-ATGL axis. COP1-ATGL modulator 1 (86) could increase ATGL protein expression, reduce ATGL ubiquitination and COP1 autoubiquitination, and diminish lipid accumulation in hepatocytes in the nanomolar range.

HY-133021

Arazine	Modulator	≥98.0%
Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site.

HY-W012248

KG-655	Modulator	99.87%
KG-655 is a small molecule compound that binds to the β-folded surface and internal cavity of ARNT PAS-B and interferes with its binding to the transcriptional coactivator TACC3. KG-655 can promote the homodimerization of ARNT PAS-B and has the potential to regulate multiple ARNT-mediated signaling pathways.

HY-128128

ASN04421891	Modulator	99.00%
ASN04421891 is a potent GPR17 receptor modulator, with an EC₅₀ of 3.67 nM in [35S]GTPγS binding assay. ASN04421891 can be used for neurodegenerative diseases research.

HY-112101

Prohydrojasmon racemate	Modulator	≥98.0%
Prohydrojasmon racemate (n-Propyl dihydrojasmonate) is the racemate of Prohydrojasmon. Prohydrojasmon is a synthesized plant growth regulator.

HY-134863

A1AT modulator 2	Modulator	98.32%
A1AT modulator 2 (compound 33) is a modulator of A1AT (α-1 antitrypsin) with an IC₅₀ value of ＞1.0 μM and an EC₅₀ value of ＜0.4 μM. A1AT modulator 2 can be used for the research of infection and inflammation.

HY-157999

SDI-118	Modulator
SDI-118 is an orally active modulator for synaptic vesicle glycoprotein 2A (SV2A) with an IC₅₀ of 13 nM.

HY-147105

LRH-1 modulator-1	Modulator
LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. LRH-1 modulator-1 shows anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 induces anti-inflammatory cytokine IL-10, and reduces inflammatory cytokine IL-1b and TNFa.

HY-156645

Tegomil fumarate	Modulator	99.72%
Tegomil fumarate is an immunomodulator.

HY-W008769

Ethychlozate	Modulator
Ethychlozate is a plant growth regulator on the promotion of flowering in citrus.

HY-P4812

Prepro-von Willebrand factor (641-650) (bovine)	Modulator
Prepro-von Willebrand factor (641-650) (bovine) is a fragment of Prepro-von Willebrand factor, which binds to type I collagen.

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