2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. PANK

PANK

Pantothenate Kinase

Pantothenate kinase (PanK) catalyzes the reaction between pantothenate (vitamin B5) and ATP to produce 4'-phosphopantothenate, the first step in the synthesis of coenzyme A (CoA). CoA plays a critical role in numerous metabolic processes, such as the synthesis and oxidation of fatty acids, complex lipid synthesis, and the oxidation of pyruvate in the citric acid cycle.
In mammals, there are four active isoforms of pantothenate kinase: PanK1α, PanK1β, PanK2, and PanK3, encoded by three different genes. Each isoform has distinct sensitivities to feedback inhibition by acetyl-CoA and is localized in different cellular compartments. For instance, PanK1α is primarily located in the nucleus, while PanK2 is mainly found in the intermembrane space of mitochondria. This specific subcellular localization allows pantothenate kinase to sense and regulate CoA levels in various cellular environments, thereby influencing critical energy metabolic pathways such as fatty acid oxidation and gluconeogenesis.
The expression and activity of pantothenate kinase are closely linked to CoA levels, affecting the body's metabolic regulation capabilities. Dysfunctions in pantothenate kinase can lead to metabolic diseases and neurodegenerative disorders. For example, Pank1 knockout mice exhibit impaired gluconeogenesis during fasting, and Pank2 knockout mice show infertility and motor dysfunctions. Additionally, PanK2 is associated with functional deficits in neurodegeneration and brain iron accumulation disease (NBIA)[1].

PANK Related Products (5):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-124634
    PZ-2891
    		Modulator 99.38%
    PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.
    PZ-2891
  • HY-44170
    Pantothenate kinase-IN-2
    		Inhibitor ≥98.0%
    Pantothenate kinase-IN-2 is a potent Pantothenate kinase 1/3 (PanK1/3) inhibitor with an IC50 of 0.14 μM and 0.36 μM. Pantothenate kinase-IN-2 is a promising agent for PKAN (PanK-associated neurodegeneration) and diabetes research.
    Pantothenate kinase-IN-2
  • HY-159509
    Claziprotamidum
    		Modulator
    Claziprotamidum (Claziprotamide) is a pantothenate kinases 1 and 3 (PanK1 and PanK3) positive allosteric modulator (PAM).
    Claziprotamidum
  • HY-144734
    Pantothenate kinase-IN-1
    		Inhibitor
    Pantothenate kinase-IN-1 (Compound 1) is a pantothenate kinase (PANK) modulator with an IC50 of 0.51 µM against PANK3. Pantothenate kinase-IN-1 has a reasonable ligand efficiency (LipE = 2.8).
    Pantothenate kinase-IN-1
  • HY-164909
    PZ-3022
    PZ-3022 is an orally active and allosteric PanK activator that counteracts C3-CoA inhibition. PZ-3022 increases hepatic CoASH and C2-CoA and decreases C3-CoA in the propionic acidemia mouse model. PZ-3022 can be used for research of mitochondrial defect in propionic acidemia.
    PZ-3022