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  4. BPN-15477

BPN-15477 is a potent SMC (splicing modulator compound) that restores correct splicing of ELP1 (Elongator complex protein 1) exon 20. BPN-15477 corrects splicing of the ELP1 transcript, significantly increases the level of functional protein in vivo in all tissues, including brain. BPN-15477 can be used for frontotemporal dementia research.

For research use only. We do not sell to patients.

BPN-15477 Chemical Structure

BPN-15477 Chemical Structure

CAS No. : 1971086-99-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 110 In-stock
Solid
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10 mg USD 170 In-stock
25 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

BPN-15477 is a potent SMC (splicing modulator compound) that restores correct splicing of ELP1 (Elongator complex protein 1) exon 20. BPN-15477 corrects splicing of the ELP1 transcript, significantly increases the level of functional protein in vivo in all tissues, including brain. BPN-15477 can be used for frontotemporal dementia research[1].

Molecular Weight

259.69

Formula

C12H10ClN5
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

ClC1=NC2=C(C=CN2)C(NCC3=CC=NC=C3)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (96.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8507 mL 19.2537 mL 38.5075 mL
5 mM 0.7701 mL 3.8507 mL 7.7015 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8507 mL 19.2537 mL 38.5075 mL 96.2686 mL
5 mM 0.7701 mL 3.8507 mL 7.7015 mL 19.2537 mL
10 mM 0.3851 mL 1.9254 mL 3.8507 mL 9.6269 mL
15 mM 0.2567 mL 1.2836 mL 2.5672 mL 6.4179 mL
20 mM 0.1925 mL 0.9627 mL 1.9254 mL 4.8134 mL
25 mM 0.1540 mL 0.7701 mL 1.5403 mL 3.8507 mL
30 mM 0.1284 mL 0.6418 mL 1.2836 mL 3.2090 mL
40 mM 0.0963 mL 0.4813 mL 0.9627 mL 2.4067 mL
50 mM 0.0770 mL 0.3851 mL 0.7701 mL 1.9254 mL
60 mM 0.0642 mL 0.3209 mL 0.6418 mL 1.6045 mL
80 mM 0.0481 mL 0.2407 mL 0.4813 mL 1.2034 mL
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BPN-15477 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPN-154771971086-99-3BPN15477BPN 15477Otherssplicing modulator compoundsSMCtarget identificationfunctional proteinfrontotemporal dementiaInhibitorinhibitorinhibit

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