2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. P2X Receptor
  5. P2X4 Receptor Isoform
  6. P2X4 Receptor Antagonist

P2X4 Receptor Antagonist

P2X4 Receptor Antagonists (6):

Cat. No. Product Name Effect Purity
  • HY-101911
    5-BDBD
    		Antagonist 99.94%
    5-BDBD, a potent and selective P2X4 receptor antagonist, inhibits rP2X4R-mediated currents, with an IC50 of 0.75 μM. 5-BDBD completely blocks the basal and acute hyperalgesia induced by nitroglycerin (NTG).
  • HY-130605
    BAY-1797
    		Antagonist 99.42%
    BAY-1797 is a potent, orally active, and selective P2X4 antagonist, with an IC50 of 211 nM against human P2X4. BAY-1797 displays no or very weak activity on the other P2X ion channels. BAY-1797 shows anti-nociceptive and anti-inflammatory effects.
  • HY-101910
    PSB-12062
    		Antagonist 98.70%
    PSB-12062 is a potent and selective P2X4 antagonist with an IC50 of 1.38 μM for human P2X4.
  • HY-110237
    BX430
    		Antagonist 99.83%
    BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. BX430 has species specificity. BX430 is used for chronic pain and cardiovascular disease.
  • HY-160677
    P2X4 antagonist-2
    		Antagonist
    P2X4 antagonist-2 is an antagonist for P2X4 with an IC50 of 24 nM.
  • HY-160645
    P2X4 antagonist-1
    		Antagonist 99.89%
    P2X4 antagonist-1 (Compound 24) is an antagonist for P2X4 with IC50 of 15 nM.