2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. PEPCK

PEPCK

Phosphoenolpyruvate Carboxykinase

PEPCK (Phosphoenolpyruvate carboxykinase) is an enzyme in the lyase family used in four pathways: gluconeogenesis, glyceroneogenesis, the synthesis of serine, and the conversion of the carbon skeletons of amino acids. PEPCK is the rate-limiting enzyme of gluconeogenesis in the liver and kidney, and is also a key regulator of TCA cycle flux. PEPCK can catalyze oxaloacetate into phosphoenolpyruvate (PEP) and carbon dioxide. PEPCK has two isoforms: PEPCK1 (PEPCK-C) and PEPCK2 (PEPCK-M). PEPCK1/PEPCK2 is distributed in the cytosol and mitochondria, and is overexpressed in many cancers[1][2].

PEPCK Related Products (6):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-128923
    SKF-34288 hydrochloride
    		Inhibitor
    SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (Ki: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides.
    SKF-34288 hydrochloride
  • HY-W115752
    Hydrazine sulfate (99%)
    		Inhibitor 99.16%
    Hydrazine sulfate is an orally active PEPCK inhibitor. Hydrazine sulfate inhibits PEPCK and low-Km ALDH. Hydrazine sulfate impairs gluconeogenesis and enhances the protective effect of energy substrates against MPP+ toxicity. Hydrazine sulfate exacerbates liver damage in rats when combined with Ethanol. Hydrazine sulfate can be used in the research of shock, non-small cell lung cancer, colorectal cancer and Parkinson's disease.
    Hydrazine sulfate (99%)
  • HY-N7912
    Pterosin A
    		Inhibitor
    Pterosin A ((2S)-Pterosin A) is a sesquiterpene compound. Pterosin A is an orally active AMPK activator with anti-diabetic effect. Pterosin A can promote glucose uptake, increase serum insulin, and improve hyperglycemia and glucose intolerance. Pterosin A can prevent insulin-secreting cells death and reduce ROS production. Pterosin A can be used for the research of metabolic disease, such as diabetes.
    Pterosin A
  • HY-111896
    7-Methoxyrosmanol
    		Inhibitor 98.56%
    7-Methoxyrosmanol (7-O-Methoxyrosmanol), a phenolic diterpene isolated from rosemary, suppresses the cAMP responsiveness of PEPCK and G6Pase promoters.
    7-Methoxyrosmanol
  • HY-N3720
    Demethoxycapillarisin
    		Inhibitor 98.0%
    Demethoxycapillarisin (6-Demethoxycapillarisin) inhibits PEPCK mRNA levels (IC50: 43 μM) by activation of the PI3K pathway. Demethoxycapillarisin decreases glucose production.
    Demethoxycapillarisin
  • HY-W197205
    SL010110
    		Degrader
    SL010110 is an anti-hyperglycemic agent. SL010110 potently inhibits gluconeogenesis by inhibiting SIRT2, activating p300, and subsequently promoting PEPCK1 degradation. SL010110 downregulates the protein level of PEPCK1 without affecting the gene expressions of PEPCK, glucose-6-phosphatase, and fructose-1,6-bisphosphatase. SL010110 significantly improves glucose homeostasis in type 2 diabetic (T2D) mice model. SL010110 can be used for T2D research.
    SL010110