2. Signaling Pathways
  3. Anti-infection
  4. Parasite
  5. Trypanosoma Isoform

Trypanosoma

Trypanosoma cruzi is a protozoan parasite transmitted by hematophagic triatomine insects (kissing bugs, reduviid bugs). Triatomine insects are the exclusive insect vectors for T. cruzi. .During a blood meal, triatomine insects defecate near the bite site, and due to the intense itching caused by triatomine saliva, individuals unknowingly rub the feces containing the infectious T. cruzi trypomastigotes into the bite wound, eye or nearby mucosal surfaces. The flagellated trypomastigotes invade various cells immediately inside the wound and transform into amastigotes. Intracellular amastigotes divide rapidly by binary fission, filling the cell and transforming back to trypomastigotes, rupturing the host cell in the process. Trypomastigotes disseminate through the bloodstream and can infect almost any tissue, repeating the amastigote-to-trypomastigote cycle. Triatomine insects may become infected during ingestion of a blood meal containing circulating trypomastigotes, thus continuing the parasite life cycle.T. cruzi can also be transmitted through other routes, including vertically to the fetus, by blood transfusion and organ transplantation.

Trypanosoma Related Products (62):

Cat. No. Product Name Effect Purity
  • HY-149080
    Antiparasitic agent-16
    		Inhibitor
    Antiparasitic agent-16, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-16 has IC50s of 1.0 μM and 0.6 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-16 has IC50s of 150.2 μM and 16.75 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-16 induces parasite cell death through necrosis induction. Antiparasitic agent-16 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes.
  • HY-B0537A
    Pentamidine dihydrochloride
    		Inhibitor
    Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.