RIP kinase Inhibitor

RIP kinase Inhibitors (124):

Cat. No.	Product Name	Effect	Purity

HY-19628A

OD36 hydrochloride	Inhibitor
OD36hydrochloride is a RIPK2 inhibitor with an IC₅₀ of 5.3 nM. OD36 hydrochloride is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 hydrochloride shows ALK2-directed activity with K_Ds of 37 nM.

HY-147235

RIPK2-IN-2	Inhibitor
RIPK2-IN-2 (example 25) is a RIP2 kinase PROTAC inhibitor. RIPK2-IN-2 can block RIP2-dependent proinflammatory signaling, regulated RIP2 kinase activity in auto inflammatory diseases.

HY-168116

RIPK1-IN-27	Inhibitor
RIPK1-IN-27 (compund 19) is a RIPK1 inhibitor.

HY-160216A

RIPK1-IN-18 sulfate hydrate	Inhibitor
RIPK1-IN-18 sulfate hydrate is a potent RIPK1 inhibitor that can be used in autoimmune diseases research (NZ748385A; compound i).

HY-157309

RIPK2-IN-4	Inhibitor
RIPK2-IN-4 is a potent and specific RIPK2 inhibitor with an IC₅₀ value of 5 nM.

HY-RS11999

Ripk3 Mouse Pre-designed siRNA Set A	Inhibitor
Ripk3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ripk3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-157963

RIPK1-IN-23	Inhibitor
RIPK1-IN-23 (compound 19) is a RIPK1 inhibitor with potent anti-necroptotic effects in HT-29 cells (EC₅₀ of 1.7 nM). RIPK1-IN-23 shows anti-inflammatory activities.

HY-162928

RIPK1-IN-26	Inhibitor
RIPK1-IN-26 (Compound 8a) is a potent receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitor with cell anti-necroptosis potency. RIPK1-IN-26 demonstrats good metabolic stability and good binding specificity in mice. RIPK1-IN-26 is promising for research of PET imaging probe development and neurodegenerative disorders.

HY-120600

Sibiriline	Inhibitor
Sibiriline is a specific competitive inhibitor of RIPK1 that targets the RIPK1 ATP-binding site and locks it in an inactive conformation. Sibiriline inhibits TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis, but does not protect cells from caspase-dependent apoptosis. Sibiriline protects mice from concanavalin A-induced hepatitis and has the potential to inhibit immune-dependent hepatitis..

HY-161843

Necroptosis-IN-4	Inhibitor
Necroptosis-IN-4, a potent necroptosis inhibitor, is a RIP kinase 1 (RIPK1) inhibitor. Necroptosis-IN-4 has no inhibitory activity against RIPK3 and weak inhibitory activity against VEGFR1/Flt-1/2 and PDGFR-α.

HY-148253

TP-030-1	Inhibitor
TP-030-1 is an inhibitor of RIPK1. TP-030-1 inhibits hRIPK1 with a K_i value of 3.9 nM and inhibits mRIPK1 with an IC₅₀ value of 4.2 μM. TP-030-1 can be used for the research of inflammatory diseases and neurodegenerative diseases.

HY-18899

Nec-3a	Inhibitor
Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC₅₀: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain.

HY-168567

RIPK2-IN-6	Inhibitor
RIPK2-IN-6 (Compound 15a) is an inhibitor for RIPK, that inhibits the phosphorylation of RIPK2, and thus inhibits the NF-κB and MAPK signaling pathways. RIPK2-IN-6 exhibits anti-inflammatory and anti-fibrotic activities in Dextran sodium sulfate (HY-116282C)-induced mice colitis models.

HY-153434

RIP1 kinase inhibitor 4	Inhibitor
RIP1 kinase inhibitor 4 (Example 3) is a BBB-penetrable RIP1 kinase inhibitor (EC₅₀: <100 nM). RIP1 kinase inhibitor 4 can be used for the research of cell programming necrosis-related diseases. RIP1 kinase inhibitor 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-149393

RIPK3-IN-3	Inhibitor
RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC₅₀=10 nM). RIPK3 mediates the phosphorylation of Mixed Lineage Kinase (MLKL) and causes necroptosis, while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosis. RIPK3-IN-3 also downregulates CXCL5 secretion and inhibits AsPC-1 cell migration and invasion.

HY-136010

RIP2 Kinase Inhibitor 4	Inhibitor
RIP2 Kinase Inhibitor 4 is a potent and selective RIPK2 PROTAC. RIP2 Kinase Inhibitor 4 effectively degrades RIPK2 (pIC₅₀ of 8) and inhibits the release of related TNF-α.

HY-123924

CSLP37	Inhibitor
CSLP37 is a selective RIPK2 inhibitor with an IC₅₀ of 16.3 nM. CSLP37 shows no inhibitory activity against RIPK1 and RIPK3. CSLP37 displays potent suppression of cellular NOD1 and NOD2 responses.

HY-161911

Necroptosis-IN-5	Inhibitor
Necroptosis-IN-5 (Compound 26) is an orally active necroptosis inhibitor. Necroptosis-IN-5 also exhibits potent inhibitory activity against receptor-interacting protein kinase 1 (RIPK1). Necroptosis-IN-5 can be used to study necroptosis-related inflammatory diseases, neurodegenerative diseases, and cancers.

HY-143726

RIPK1-IN-8	Inhibitor
RIPK1-IN-8 (example 16), an aminoimidazopyridine, is a potent and selective RIPK1 inhibitor with an IC₅₀ of 4 nM. RIPK1-IN-8 has the potential for inflammatory diseases research.

HY-148052

RIPK3-IN-2	Inhibitor
RIPK3-IN-2 is a RIP3 inhibitor. RIPK3-IN-2 can be used in diseases caused by or associate with activated necrotic pathways research.

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