TP-030-1

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TP-030-1 is an inhibitor of RIPK1. TP-030-1 inhibits hRIPK1 with a K_i value of 3.9 nM and inhibits mRIPK1 with an IC₅₀ value of 4.2 μM. TP-030-1 can be used for the research of inflammatory diseases and neurodegenerative diseases.

For research use only. We do not sell to patients.

TP-030-1 Chemical Structure

CAS No. : 2095514-75-1

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Biological Activity
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References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	IC₅₀	18 nM Compound: 14	Induction of necroptosis in human HT-29 cells assessed as increase in TNFalpha/AT-406/zVAD-FMK-induced LDH release preincubated with cells followed by TNFalpha/AT-406/zVAD-FMK addition measured after 16 to 20 hrs by CytoTox 96 nonradioactive cytotoxicity Induction of necroptosis in human HT-29 cells assessed as increase in TNFalpha/AT-406/zVAD-FMK-induced LDH release preincubated with cells followed by TNFalpha/AT-406/zVAD-FMK addition measured after 16 to 20 hrs by CytoTox 96 nonradioactive cytotoxicity	[PMID: 29485864]

In Vitro

TP-030-1 inhibits HT29 necroptosis with an IC₅₀ value of 18 nM^[1].
TP-030-1 inhibits hRIPK1 with a K_i value of 3.9 nM^[1].
TP-030-1 inhibits mRIPK1 with an IC₅₀ value of 4.2 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

402.45

Formula

C₂₃H₂₂N₄O₃

CAS No.

2095514-75-1

SMILES

O=C1[C@@H](N2CCC3=CN(CC4=CC=CC=C4)N=C3C2=O)COC5=CC=CC=C5N1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Msato Yoshikawa, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure–Kinetic Relationships. J. Med. Chem. 2018, 61, 6, 2384–2409.

TP-030-1 Related Classifications

Neurological Disease Inflammation/Immunology

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TP-030-12095514-75-1RIP kinaseReceptor-interacting protein kinasesRIPKHT29inflammationprobeinhibitorneurodegenerative diseaseInhibitorinhibit

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