Cinnamyl Alcohol

Name: Cinnamyl Alcohol
Brand: MedChemExpress
SKU: HY-Y0078
Rating: 5.0 (2 reviews)

Cat. No.: HY-Y0078 Purity: 99.80%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity.

For research use only. We do not sell to patients.

Cinnamyl Alcohol Chemical Structure

CAS No. : 104-54-1

Size	Stock	Quantity

Free Sample (0.1 - 0.5 mg)	Apply Now
Solid or liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid or liquid
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Cinnamyl Alcohol:

2 Publications Citing Use of MCE Cinnamyl Alcohol

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All PPAR Isoform Specific Products:

View All Isoforms

PPARα PPARβ/δ PPARγ PPAR PPARδ

View All NO Synthase Isoform Specific Products:

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nNOS iNOS eNOS

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View All Isoforms

ROCK ROCK1 ROCK2

View All ERK Isoform Specific Products:

View All Isoforms

ERK ERK1 ERK2 ERK5 ERK8

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View All Isoforms

Akt Akt1 Akt2 Akt3

View All AMPK Isoform Specific Products:

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity^[1].

In Vitro

Cinnamyl Alcohol (0.5-1 µg/µL, 24 h) inhibits LPS (HY-D1056) and IFN-γ-induced NO production in cell RAW264.7 through inhibition of iNOS^[4].
Cinnamyl Alcohol (0.4-2 mM, 24 h) activates K+ channels via the NO-cGMP-PKG pathway, inhibits Rho kinase, and attenuates Phenylephrine (HY-B0769)-induced vasoconstriction in rat thoracic aorta endothelial cells^[3].
Cinnamyl Alcohol (25 µM, 24-48 h) downregulates the expressions of adipogenesis-related proteins PPARγ, C/EBPα, FABP4 and adipogenesis-related proteins C/EBPβ, C/EBPδ, cyclin B1/D1/E1, and CDK2/6, arrests cell cycle at G0/G1 phase in 3T3-L1 cells, and inhibits the lipid accumulation^[2].
Cinnamyl Alcohol (25 µM, 60 min) activates the AMPKα phosphorylation, inhibits AKT and ERK1/2 signaling pathway^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	3T3-L1
Concentration:	25 µM
Incubation Time:	16-20 h
Result:	Downregulated expressions of PPARγ, C/EBPα, FABP4, C/EBPβ, C/EBPδ, cyclin B1/D1/E1, CDK2/6.

Cell Cycle Analysis^[2]

Cell Line:	3T3-L1
Concentration:	25 µM
Incubation Time:	24-48 h
Result:	Arrested cell cycle at G0/G1 phase.

Western Blot Analysis^[4]

Cell Line:	RAW246.7
Concentration:	0.5-1 µg/µL
Incubation Time:	24 h
Result:	Inhibited expression of iNOS.

In Vivo

Cinnamyl Alcohol (2 g/kg, po, single dose) exhibits anti-inflammatory activity in E. coli-induced sepsis mouse model^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mouse E. coli-induced sepsis model^[5]
Dosage:	2 g/kg
Administration:	po, single dose
Result:	Reduced the inflammatory reaction in the liver, heart, lungs, and kidneys

Molecular Weight

134.18

Formula

C₉H₁₀O

CAS No.

104-54-1

Appearance

<30°C Solid,>33°C Liquid

Color

White to light yellow

SMILES

OC/C=C/C1=CC=CC=C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (1863.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (745.28 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.4528 mL	37.2639 mL	74.5279 mL
5 mM	1.4906 mL	7.4528 mL	14.9056 mL
10 mM	0.7453 mL	3.7264 mL	7.4528 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 6.25 mg/mL (46.58 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 6.25 mg/mL (46.58 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 6.25 mg/mL (46.58 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.80%

Select Batch:

Data Sheet (277 KB) SDS (796 KB)

COA (244 KB) HNMR (259 KB) RP-HPLC (87 KB)

Handling Instructions (2659 KB)

References

[1]. Hwang DI, et al. Cinnamyl Alcohol, the Bioactive Component of Chestnut Flower Absolute, Inhibits Adipocyte Differentiation in 3T3-L1 Cells by Downregulating Adipogenic Transcription Factors. Am J Chin Med. 2017;45(4):833-846. [Content Brief]

[2]. Choi YR, et al., Cinnamyl Alcohol Attenuates Adipogenesis in 3T3-L1 Cells by Arresting the Cell Cycle. Int J Mol Sci. 2024 Jan 5;25(2):693. [Content Brief]

[3]. Kang YH, et al., Cinnamyl alcohol attenuates vasoconstriction by activation of K⁺ channels via NO-cGMP-protein kinase G pathway and inhibition of Rho-kinase. Exp Mol Med. 2012 Dec 31;44(12):749-55. [Content Brief]

[4]. Lee H S. Chemical composition of Cinnamomum cassia leaf oils and suppression effect of cinnamyl alcohol on nitric oxide synthase[J]. Journal of the Korean Society for Applied Biological Chemistry, 2009, 52: 480-485.

[5]. Zou L, et al., The anti-inflammatory effects of cinnamyl alcohol on sepsis-induced mice via the NLRP3 inflammasome pathway. Ann Transl Med. 2022 Jan;10(2):48. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	7.4528 mL	37.2639 mL	74.5279 mL	186.3197 mL
	5 mM	1.4906 mL	7.4528 mL	14.9056 mL	37.2639 mL
	10 mM	0.7453 mL	3.7264 mL	7.4528 mL	18.6320 mL
	15 mM	0.4969 mL	2.4843 mL	4.9685 mL	12.4213 mL
	20 mM	0.3726 mL	1.8632 mL	3.7264 mL	9.3160 mL
	25 mM	0.2981 mL	1.4906 mL	2.9811 mL	7.4528 mL
	30 mM	0.2484 mL	1.2421 mL	2.4843 mL	6.2107 mL
	40 mM	0.1863 mL	0.9316 mL	1.8632 mL	4.6580 mL
	50 mM	0.1491 mL	0.7453 mL	1.4906 mL	3.7264 mL
	60 mM	0.1242 mL	0.6211 mL	1.2421 mL	3.1053 mL
	80 mM	0.0932 mL	0.4658 mL	0.9316 mL	2.3290 mL
	100 mM	0.0745 mL	0.3726 mL	0.7453 mL	1.8632 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.