Ras

Related Products

Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells. Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. As a result, mutations in ras genes can lead to the production of permanently activated Ras proteins. This can cause unintended and overactive signalling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRAS,KRAS, and NRAS) are the most common oncogenes in human cancer; Ras inhibitors are being studied as a treatment for cancer, and other diseases with Ras overexpression.

Ras Isoform Specific Products:

Ras Isoform Comparison

Ras Related Products (501)
Antibodies (36)
Ras Isoform Comparison

By Effects:	Controls (7) Ligands (3) Inhibitors (416) Agonists (7) Degraders (17) Antagonists (3) Activators (20) Modulators (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-142458

KRAS G12C inhibitor 27	Inhibitor
KRAS G12C inhibitor 27 is a KRAS G12C inhibitor with antitumor effects (WO2021109737).

HY-115880

KRAS G12D inhibitor 3	Inhibitor
KRAS G12D inhibitor 3 is a KRAS G12D inhibitor with an IC₅₀ of <500 nM. KRAS G12D inhibitor 3 has antitumor effects (WO2022002102A1; compound 146). KRAS G12D inhibitor 3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-170428

IPS-06061	Degrader
IPS-06061 is an orally active molecule glue, that forms a ternary complex of CRBN-KRASG12D-IPS06061, and degrades KRAS G12D with a DC₅₀ <500 nM.

HY-153262

KRASG12C IN-2	Inhibitor
KRASG12C IN-2 (compound 17) is an orally active KRAS^G12C inhibitor. KRASG12C IN-2 inhibits tumor growth in mice.

HY-150927

G12Si-2	Inhibitor
G12Si-2, an analog of G12Si-1 (HY-150926), is a negative control tool. G12Si-2 is not a covalent inhibitor of the G12S mutant of K-Ras.

HY-150926

G12Si-1	Inhibitor
G12Si-1 is a selective K-Ras(G12S) covalent inhibitor, which can inhibit oncogenic signaling of K-Ras(G12S). G12Si-1 shows good ability to covalently engage recombinant K-Ras(G12S) at the mutant serine residue. G12Si-1 can also affect nucleotide cycling of K-Ras by blocking Sos-catalyzed exchange and decreasing the rate of EDTA promoted exchange.

HY-129189

RAS GTPase inhibitor 1	Inhibitor
RAS GTPase inhibitor 1 (example 51) is a RAS GTPase inhibitor with anti-tumor activity, extracted from patent WO2018212774A1. RAS GTPase inhibitor 1 (example 51) exhibits an EC₅₀ less than 1 μM for at least one nucleotide exchange and an IC₅₀ less than 1 μM in H727 cells.

HY-114168

KRAS G12C inhibitor 5	Inhibitor
KRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147.

HY-132979

KRAS G12C inhibitor 18	Inhibitor
KRAS G12C inhibitor 18 is a potent and orally active KRAS G12C inhibitor. Anti-tumor activities.

HY-126292

KRAS G12C inhibitor 13	Inhibitor
KRAS G12C inhibitor 13 is a KRAS G12C inhibitor extracted from patent WO2018143315A1, compound 30.

HY-151287

KRAS inhibitor-20	Inhibitor
KRAS inhibitor-20 is a small molecular inhibitor of KRas^G12C, the oncogenic mutant. KRAS inhibitor-20 inhibits KRas^G12C with the IC50 value <10 nM.

HY-146546

KRAS inhibitor-16	Inhibitor
KRAS inhibitor-16 (compound 3-11) is a potent KRAS G12C inhibitor with an IC₅₀ of 0.457 µM. KRAS inhibitor-16 shows p-ERK inhibition activities with IC₅₀s of 3.06, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-16 has the potential for the research of pancreatic, colorectal, and lung cancers.

HY-162249

ASP6918	Inhibitor
ASP6918 is a potent and orally active KRAS G12C inhibitor with an IC₅₀ value of 0.028 µM. ASP6918 inhibits cell growth. ASP6918 shows antitumor activity.

HY-125875

KRAS G12C inhibitor 17	Inhibitor
KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 82, has an IC₅₀ of 5 nM.

HY-144212

SOS1-IN-8	Inhibitor
SOS1-IN-8 is a potent SOS1 inhibitor with IC₅₀s of 11.6 and 40.7 nM for SOS1-G12D and SOS1-G12V, respectively (WO2022017339A1, compound 2).

HY-130260

KRAS inhibitor-4	Inhibitor
KRAS inhibitor-4 (compound F12) is a potent KRAS inhibitor and developed as anticancer agents.

HY-146544

KRAS inhibitor-14	Inhibitor
KRAS inhibitor-14 (compound 3-22) is a potent KRAS G12C inhibitor with an IC₅₀ of 0.249 µM. KRAS inhibitor-14 shows p-ERK inhibition activities with IC₅₀s of 1.12, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-14 has the potential for the research of pancreatic, colorectal, and lung cancers.

HY-125874

KRAS G12C inhibitor 16	Inhibitor
KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 39, has an IC₅₀ of 97 nM.

HY-159163

KRASG12C IN-12	Inhibitor
KRASG12C IN-12 (compound-1) is a KRAS^G12C inhibitor. KRASG12C IN-12 (compound-1) can form a ternary complex with intracellular CYPA and the activated KRAS^G12C mutant.

HY-142478

KRAS G12C inhibitor 29	Inhibitor
KRAS G12C inhibitor 29 is a KRAS G12C inhibitor extracted from patent WO2021252339A1, compound 3. KRAS G12C inhibitor 29 can be used for the research of cancer.

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Ras

Ras

Ras Isoform Specific Products:

Ras Isoform Specific Products:

Ras Related Products (501)

Antibodies (36)

Ras Isoform Comparison

Ras Related Products (501):