2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. SGLT

SGLT

Sodium-dependent glucose cotransporters

SGLT

Related Products

PDF 0.51 MB

SGLTs (Sodium-dependent glucose cotransporters) are a family of glucose transporters and contribute to glucose reabsorption. The two most well-known members of SGLT family are SGLT1 and SGLT2, which are members of the SLC5A gene family. The two transporters are of primary importance for glucose homeostasis by absorbing glucose from the diet in the small intestine (via SGLT1) and by reabsorbing the filtered glucose in the tubular system of the kidney (primarily SGLT2; to smaller extent via SGLT1); the latter process returns glucose into the blood stream and prevents urinary glucose loss. SGLT1 and SGLT2 have been proposed as a novel therapeutic strategy for diabetes and cardiomyopathy.

SGLT Isoform Specific Products:

SGLT Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14894R
    Ipragliflozin (Standard)
    		Inhibitor
    Ipragliflozin (Standard) is the analytical standard of Ipragliflozin. This product is intended for research and analytical applications. Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent.
    Ipragliflozin (Standard)
  • HY-15409R
    Empagliflozin (Standard)
    		Inhibitor
    Empagliflozin (Standard) is the analytical standard of Empagliflozin. This product is intended for research and analytical applications. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2.
    Empagliflozin (Standard)
  • HY-N0143R
    Phlorizin (Standard)
    		Inhibitor
    Phlorizin (Standard) is the analytical standard of Phlorizin. This product is intended for research and analytical applications. Phlorizin (Floridzin) is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.
    Phlorizin (Standard)
  • HY-14894S2
    Pragliflozin-13C6
    		Inhibitor
    Pragliflozin-13C6 (ASP1941-13C6) is 13C labeled Ipragliflozin. Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent.
    Pragliflozin-<sup>13</sup>C<sub>6</sub>
  • HY-124664
    TP0438836
    		Inhibitor
    TP0438836 (compound 30b) is a SGLT1 inhibitor, with IC50 values ​​of 28 nM and 7 nM for hSGLT1 and hSGLT2, respectively. TP0438836 can be used in diabetes research.
    TP0438836
  • HY-165438
    Sergliflozin-A
    		Inhibitor
    Sergliflozin-A is a compound used to inhibit type 2 diabetes. It can inhibit glucose transporters in the kidney, competitively inhibit hSGLT1 and hSGLT2, and mutations at different sites have different effects on its inhibitory effect.
    Sergliflozin-A
  • HY-137145
    galacto-Dapagliflozin
    		Inhibitor
    Galacto-dapagliflozin is a selective inhibitor for hSGLT2 with Ki of 25 nM.
    galacto-Dapagliflozin
  • HY-14902
    Tofogliflozin
    		Inhibitor
    Tofogliflozin(CSG-452) is a potent and highly specific sodium/glucose cotransporter 2(SGLT2) inhibitor with Ki values of 2.
    Tofogliflozin
  • HY-122473
    fluoro-Dapagliflozin
    		Inhibitor
    fluoro-Dapagliflozin, a structural analog of Dapagliflozin, is a selective SGLT2 inhibitor with Ki values of 5.3 nM and 330 nM for SGLT2 and SGLT1, respectively. fluoro-Dapagliflozin blocks glucose transport and glucose-coupled currents.
    fluoro-Dapagliflozin
SGLT Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.