2. Signaling Pathways
  3. Immunology/Inflammation
  4. STING

STING

Stimulator of Interferon Genes; TMEM173; MITA; ERIS; MPYS

STING

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Stimulator of interferon genes (STING) is an integral ER-membrane protein that can be activated by 2'3'-cGAMP synthesized by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) upon binding of double-stranded DNA. It activates interferon (IFN) and inflammatory cytokine responses to defend against infection by microorganisms.

STING is a key cytosolic receptor for small nucleotides and plays a key role in anticancer and antiviral immunity. STING signaling pathway is also a critical link between innate and adaptive immunity, and induces anti-tumor immune responses. STING agonists, such as endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP), have been used in diverse research for immunogenic tumor clearance, antiviral treatments and vaccine adjuvants.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-160223
    ssVACV-70mer sodium
    ssVACV-70mer sodium is a 70 bp single-stranded oligonucleotide containing viral DNA motifs that derive from the vaccinia virus DNA. Unlike its double-stranded counterpart dsVACV 70mer, ssVACV 70mer is not IFN-inducer.
    ssVACV-70mer sodium
  • HY-152958
    STING agonist-25
    		Agonist
    STING agonist-25 (CF505) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains.
    STING agonist-25
  • HY-168554
    STING-IN-10
    		Degrader
    STING-IN-10 (P8) is a dual STING degrader and inhibitor with aDC50 value of 2.58 μM in THP-1 cells. STING-IN-10 has anti-inflammatory activity.
    STING-IN-10
  • HY-160222
    HSV-60mer sodium
    		Activator
    HSV-60mer sodium is a 60 bp double-stranded oligonucleotide containing viral DNA motifs that derive from the herpes simplex virus 1 (HSV-1) genome. Transfected HSV-60 has been shown to potently induce IFN-β in a Toll-like receptor (TLR)-, DNA-dependent activator of IRFs (DAI)-, and RNA polymerase III (Pol III)-independent, but STING-, TBK1- and IFN regulatory factor 3 (IRF3)-dependent manner.
    HSV-60mer sodium
  • HY-148460
    Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine
    		Agonist
    Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine is an immune stimulator antibody conjugate (ISAC) comprising an anti-human epidermal growth factor receptor 2 (HER2) antibody, a STING agonist (ADU-S100) and a linker. Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine can be uesd for cancer research (WO2018200812A1; example 5).
    Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine
  • HY-158349
    Mal-Val-Ala-PAB-4-Abu(Me)-Dazostinag
    Mal-Val-Ala-PAB-4-Abu(Me)-Dazostinag is a drug-linker conjugate for ADC.
    Mal-Val-Ala-PAB-4-Abu(Me)-Dazostinag
  • HY-139179
    STING agonist-14
    		Agonist
    STING agonist-14 (compound 12b) is a potent STING agonist that is efficacious across species. STING agonist-14 could activate the pathway by directly binding human STING. STING agonist-14 can be used for the research of tumours or viral infections.
    STING agonist-14
  • HY-149267
    STING agonist-30
    		Agonist
    STING agonist-30 is a potent STING agonist. STING agonist-30 exhibits STING-dependent immune activation. STING agonist-30 has extensive inhibitory effects on various viruses, including the herpes simplex virus (HSV), rotavirus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
    STING agonist-30
  • HY-148420
    CDN-A
    		Activator
    CDN-A is a cyclic di-nucleotide, it can be used to synthesis antibody-drug conjugate (ADC). Cyclic di-nucleotides are potent stimulators of innate and adaptive immune responses. In humans, cyclic di-nucleotide, which are either produced endogenously in response to foreign DNA or by invading bacterial pathogens, trigger the innate immune system by activating the expression of interferon genes.
    CDN-A
  • HY-144328
    STING agonist-10
    		Activator
    STING agonist-10 (Compound 91) is a potent small molecule cyclic urea activator of STING with the EC50 of 2600 nM. Activation of STING is a highly promising approach in immunotherapy.
    STING agonist-10
  • HY-160910
    STING agonist-35
    		Agonist
    STING agonist-35 (Compoind 1a) is an agonist for stimulator of interferon genes (STING), which activates the wild type STING and mutated type STING (R232H), with a rate of 99% and 92%. STING agonist-35 is a potent payload for ADC.
    STING agonist-35
  • HY-163749
    STING-IN-8
    		Inhibitor
    STING-IN-8 (Compound 15b) emerges as a potent stimulator of interferon gene (STING) inhibitor with an IC50 value of 0.121 μM in human and an IC50 value of 0.033 μM in mouse. STING-IN-8 inhibits MSA-2 (HY-136927) or 2’, 3’ -cGAMP (HY-100564)-stimulated STING signaling and suppresses immune-inflammatory cytokine levels in both human and murine cells. STING-IN-8 is promising for research in the field of STING-associated inflammatory and autoimmune diseases.
    STING-IN-8
  • HY-151264
    BSP16
    		Inhibitor
    BSP16 is a potent, orally active stimulator of interferon genes (STING) agonist. BSP16 can selectively stimulate the STING pathway. BSP16 can be used for the research of cancer.
    BSP16
  • HY-148546
    STING agonist-21
    		Agonist
    STING agonist-21 (compound 1) is a STING agonist, with an EC50 of 592.8 nM. STING agonist-21 can be used for cancer research.
    STING agonist-21
  • HY-139586B
    Ulevostinag (isomer 2)
    		Agonist
    Ulevostinag isomer 2 (MK-1454 isomer 2) is the isomer of Ulevostinag. Ulevostinag is a STING agonist.
    Ulevostinag (isomer 2)
  • HY-158711
    STING agonist-38
    		Agonist
    STING agonist-38 (compound 58) is a potent agonist of STING, with the EC50 of 0.05 μM in THP1 cells. STING agonist-38 has certain oral bioactivity.
    STING agonist-38
  • HY-149724
    Anti-inflammatory agent 65
    		Inhibitor
    Anti-inflammatory agent 65 (compound 29) is a Hederagonic acid derivative with potent anti-inflammatory activity. Anti-inflammatory agent 65 inhibits nitric oxide (NO) release. Anti-inflammatory agent 65 inhibits the nuclear translocation of IRF3 and p65, and disrupts the STING/IRF3/NF-κB signaling pathway, thereby attenuating the inflammatory response.
    Anti-inflammatory agent 65
  • HY-163643
    STING modulator-7
    		Modulator
    STING modulator-7 (compound 132) is a modulator of STING,.
    STING modulator-7
  • HY-139586C
    Ulevostinag (isomer 3)
    		Agonist
    Ulevostinag (isomer 3) (example 246) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (isomer 3) plays an important role in anti-tumor research.
    Ulevostinag (isomer 3)
  • HY-139586D
    Ulevostinag (isomer 4)
    		Agonist
    Ulevostinag isomer 4 (MK-1454 isomer 4) is the isomer of Ulevostinag. Ulevostinag is a STING agonist.
    Ulevostinag (isomer 4)
Cat. No. Product Name / Synonyms Application Reactivity