2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Sodium Channel
  5. Nav1.4 Isoform
  6. Nav1.4 Antagonist

Nav1.4 Antagonist

Nav1.4 Antagonist (1):

Cat. No. Product Name Effect Purity
  • HY-P1681
    GpTx-1
    		Antagonist
    GpTx-1 is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. GpTx-1 demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM, while exhibiting excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM), showing >20-fold and >950-fold selectivity respectively.